| Princess Charlotte | |
| Full Name: | German: Marie Charlotte Amalie Ernestine Wilhelmine Philippine |
| Consort: | yes |
| Succession: | Duchess consort of Saxe-Gotha-Altenburg |
| Reign: | 10 March 1772 – 20 April 1804 |
| Issue: | Ernest, Hereditary Prince of Saxe-Gotha-Altenburg Augustus Frederick IV Prince Ludwig |
| House: | Saxe-Meiningen |
| Father: | Anton Ulrich, Duke of Saxe-Meiningen |
| Mother: | Landgravine Charlotte Amalie of Hesse-Philippsthal |
| Birth Date: | 11 September 1751 |
| Birth Place: | Frankfurt am Main, Free Imperial City of Frankfurt, Holy Roman Empire |
| Death Place: | Genoa, Kingdom of Sardinia |
Princess Charlotte of Saxe-Meiningen (German: Marie Charlotte Amalie Ernestine Wilhelmine Philippine, Prinzessin von Sachsen-Meiningen) (11 September 1751, Frankfurt am Main, Free Imperial City of Frankfurt, Holy Roman Empire - 25 April 1827, Genoa, Kingdom of Sardinia) was a member of the House of Saxe-Meiningen and a Princess of Saxe-Meiningen by birth and a member of the House of Saxe-Gotha-Altenburg and Duchess consort of Saxe-Gotha-Altenburg through her marriage to Ernest II, Duke of Saxe-Gotha-Altenburg.
Princess Charlotte was born on 11 September 1751. She was the eldest child and daughter of Anton Ulrich, Duke of Saxe-Meiningen and his second wife, Landgravine Charlotte Amalie of Hesse-Philippsthal. Charlotte was an elder sister of Charles William, Duke of Saxe-Meiningen and George I, Duke of Saxe-Meiningen.
Charlotte married Ernest, Hereditary Prince of Saxe-Gotha-Altenburg (later Duke of Saxe-Gotha-Altenburg), son of Frederick III, Duke of Saxe-Gotha-Altenburg and his wife Luise Dorothea of Saxe-Meiningen, on 21 March 1769 in Meiningen. Charlotte and Ernest had four children:
Charlotte's husband, Ernest, was regarded as an enlightened monarch and a great patron of art and science, who led his country into a cultural flowering. He was assisted in his cultural undertakings by his wife, Charlotte.
Like her husband, Charlotte was a patron of astronomy. She counted relief panels for the court astronomer Franz Xaver von Zach and she also participated in observations. Charlotte also participated in the First European Astronomy Congress in 1798 at the Seeberg Observatory and independently corresponded with the leading astronomers of her time.
After her husband's death in 1804, there were difficulties with Charlotte's son, Augustus, upon his succession. Charlotte left Gotha with Zach and spent some time in Eisenberg. Later she traveled with Zach throughout southern Europe and lived several years in Marseilles, and later in Genoa, where she died in 1827.