| Princess Charlotte Sophie | |
| Duchess Louis of Mecklenburg-Schwerin | |
| Spouse: | Duke Louis of Mecklenburg-Schwerin |
| Issue: | Frederick Francis I, Grand Duke of Mecklenburg-Schwerin Sophia Frederica, Hereditary Princess of Denmark and Norway |
| House: | Wettin |
| Father: | Francis Josias, Duke of Saxe-Coburg-Saalfeld |
| Mother: | Princess Anna Sophie of Schwarzburg-Rudolstadt |
| Birth Date: | 24 September 1731 |
| Birth Place: | Coburg |
| Death Place: | Schwerin |
Princess Charlotte Sophie of Saxe-Coburg-Saalfeld, Duchess in Saxony (24 September 1731 – 2 August 1810) was a German duchess. She was the daughter of Franz Josias, Duke of Saxe-Coburg-Saalfeld and Princess Anna Sophie of Schwarzburg-Rudolstadt.
Charlotte Sophie married Duke Louis of Mecklenburg-Schwerin (6 August 1725 – 12 September 1778), younger son of Christian Ludwig II, Duke of Mecklenburg-Schwerin. They had two children:
| Name | Birth | Death | Marriage/notes | |
|---|---|---|---|---|
| Friedrich Franz | 10 December 1756 | 1 February 1837 | Princess Louise of Saxe-Gotha-Altenburg m. 1 June 1775 at Gotha; had issue | |
| Sophia Frederica | 24 August 1758 | 29 November 1794 | Hereditary Prince Frederick of Denmark and Norway m. 21 October 1774 at Copenhagen; had issue (including Christian VIII of Denmark) |