| Charlie Duffee | |
| Position: | Outfielder |
| Birth Date: | 27 January 1866 |
| Birth Place: | Mobile, Alabama, U.S. |
| Death Place: | Mobile, Alabama, U.S. |
| Bats: | Right |
| Throws: | Right |
| Debutleague: | MLB |
| Debutdate: | April 17 |
| Debutyear: | 1889 |
| Debutteam: | St. Louis Browns |
| Finalleague: | MLB |
| Finaldate: | April 30 |
| Finalyear: | 1893 |
| Finalteam: | Cincinnati Reds |
| Statleague: | MLB |
| Stat3label: | Runs batted in |
| Stat3value: | 281 |
| Stat2label: | Home runs |
| Stat2value: | 35 |
| Stat1label: | Batting average |
| Stat1value: | .267 |
| Teams: |
|
Charles Edward Duffee (January 27, 1866 – December 24, 1894), was a Major League Baseball outfielder from -, for the St. Louis Browns, Cincinnati Reds, Columbus Solons, and Washington Senators. He left baseball because he was in poor health. He died on Christmas Eve of 1894 at age 28.