| Karl Wilhelm | |
| Succession: | Duke of Saxe-Meiningen |
| Reign: | 27 January 1763 - 21 July 1782 |
| Full Name: | August Frederick Karl Wilhelm |
| Predecessor: | Anton Ulrich |
| Successor: | Georg I |
| Regent: | The Dowager Duchess |
| Spouse: | Louise of Stolberg-Gedern |
| House: | Saxe-Meiningen |
| Father: | Anton Ulrich, Duke of Saxe-Meiningen |
| Mother: | Charlotte Amalie of Hesse-Philippsthal |
| Birth Date: | 19 November 1754 |
| Birth Place: | Frankfurt, Frankfurt, Holy Roman Empire |
| Death Place: | Sonneberg, Saxe-Coburg-Saalfeld, Holy Roman Empire |
| Religion: | Lutheranism |
August Friedrich Karl Wilhelm, Duke of Saxe-Meiningen[1] (19 November 1754 - 21 July 1782), was a duke of Saxe-Meiningen.
He was the first son of Anton Ulrich, Duke of Saxe-Meiningen and Charlotte Amalie of Hesse-Philippsthal.
August Friedrich succeeded his father in the duchy of Saxe-Meiningen (1763) when he was only eight years old. Because of this, his mother, the Dowager Duchess Charlotte Amalie, acted as regent during his minority, which ended in 1779. He was succeeded by his last younger surviving brother, Georg.
In Gedern on 5 June 1780, Karl Wilhelm married Louise of Stolberg-Gedern. They had no children. The widowed Louise later married Duke Eugen of Württemberg and had issue.