| Charles Defrémery | |
| Birth Date: | 8 December 1822 |
| Birth Place: | Cambrai (Nord) |
| Death Place: | Saint-Valery-en-Caux (Seine-Maritime) |
| Occupation: | Orientalist |
Charles Defrémery (8 December 1822 – 18 August 1883) was a 19th-century French orientalist, specialist in Arabic and Persian history and literature.
He held the chair of Arabic language and literature at the École des langues orientales and was a member of the Société Asiatique of Paris. On 2 December 1860, he was appointed corresponding member of the St Petersburg Academy of Sciences for the Oriental literary department. He was elected a member of the Académie des inscriptions et belles-lettres in 1869. From 1871, he held the chair of Arabic at the Collège de France.