| Charles Wyche | |
| Office: | Judge of the United States District Court for the District of South Carolina |
| Term Start: | November 1, 1965 |
| Term End: | September 17, 1966 |
| Appointer: | operation of law |
| Predecessor: | Seat established by 79 Stat. 951 |
| Successor: | Donald S. Russell |
| Office1: | Chief Judge of the United States District Court for the Western District of South Carolina |
| Term Start1: | 1948 |
| Term End1: | 1962 |
| Predecessor1: | Office established |
| Successor1: | James Robert Martin Jr. |
| Office2: | Judge of the United States District Court for the Western District of South Carolina |
| Term Start2: | January 30, 1937 |
| Term End2: | November 1, 1965 |
| Appointer2: | Franklin D. Roosevelt |
| Predecessor2: | Henry Hitt Watkins |
| Successor2: | Seat abolished |
| Birth Name: | Charles Cecil Wyche |
| Birth Date: | 7 July 1885 |
| Birth Place: | Prosperity, South Carolina |
| Death Place: | Spartanburg, South Carolina |
| Education: | The Citadel (B.S.) Georgetown Law read law |
Charles Cecil Wyche (July 7, 1885 – September 17, 1966) was a United States district judge of the United States District Court for the Western District of South Carolina and the United States District Court for the District of South Carolina.
Born in Prosperity, South Carolina, Wyche received a Bachelor of Science degree from The Citadel in 1906 and attended Georgetown Law, but read law to enter the Bar in 1909. He was in private practice in Spartanburg, South Carolina from 1909 to 1937. He served in the South Carolina House of Representatives from 1913 to 1914. He was a Major in the United States Army during World War I from 1917 to 1919. He was a city attorney for Spartanburg from 1919 to 1922, and a county attorney for Spartanburg County from 1919 to 1933. He was a special judge of the Circuit Court of Cherokee County, South Carolina in 1924. He was a special associate justice of the Supreme Court of South Carolina in 1929. From 1933 to 1937 he was the United States Attorney for the Western District of South Carolina.
Wyche was nominated by President Franklin D. Roosevelt on January 11, 1937, to a seat on the United States District Court for the Western District of South Carolina vacated by Judge Henry H. Watkins. He was confirmed by the United States Senate on January 22, 1937, and received his commission on January 30, 1937. He served as Chief Judge from 1948 to 1962. Wyche was reassigned by operation of law to the United States District Court for the District of South Carolina on November 1, 1965, to a new seat authorized by 79 Stat. 951. His service terminated on September 17, 1966, due to his death.