| Honorific-Prefix: | The Hon. |
| Charles-Christophe Malhiot | |
| Office: | Senator for De la Vallière, Quebec |
| Successor: | Anselme-Homère Pâquet |
| Term Start: | October 23, 1867 |
| Term End: | November 9, 1874 |
| Appointed: | Royal Proclamation |
| Birth Date: | 11 October 1808 |
| Birth Place: | Verchères, Lower Canada |
| Death Place: | Pointe-du-Lac, Quebec |
| Party: | Liberal |
| Alma Mater: | College of Montreal |
| Occupation: | Doctor, Politician |
Charles-Christophe Malhiot (October 11, 1808 - November 9, 1874) was a medical doctor and a member of the Senate of Canada from 1867 until his death.
He was born in Verchères in Lower Canada, the son of François-Xavier Malhiot, the seigneur of Verchères. He studied medicine and settled at Yamachiche. In 1835, he married Julie-Éliza Montour, the daughter of Nicholas Montour, Seigneur of Pointe-du-Lac. He was mayor of Pointe-du-Lac from 1859 to 1864. In 1862, he was elected for a six-year term to the Legislative Council of the Province of Canada representing Shawinigan. After Confederation, he was appointed to the Senate as a member of the Liberal Party.
He died at Pointe-du-Lac in 1874.