Charantoside Explained

Charantoside is any of several related cucurbitane triterpenoid glycosides found in the fruits bitter melon vine (Momordica charantia).^[1] They include:

• charantoside I, (19R,23E)-5β,19-Epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol 3-O-β-D-glucopyranoside: amorphous solid.
• charantoside II, (19R,23R)-5β,19-Epoxy-19,23-dimethoxycucurbita-6,24-dien-3β-ol 3-O-β-D-allopyranoside: amorphous solid.
• charantoside III, (23E)-5β,19-Epoxycucurbita-6,23,25-trien-3β-ol 3-O-β-D-glucopyranoside: amorphous solid.
• charantoside IV, (23E)-5β,19-Epoxycucurbita-6,23,25-trien-3β-ol 3-O-β-D-allopyranoside: colorless needles, melting at 256–260 °C.
• charantoside V, (23R)-5β,19-Epoxy-23-methoxycucurbita-6,24-dien-3β-ol 3-O-β-D-glucopyranoside: colorless needles, melting at 235–240 °C.
• charantoside VI, (23S)-5β,19-Epoxy-23-methoxycucurbita-6,24-dien-3β-ol 3-O-β-D-allopyranoside: amorphous solid.
• charantoside VII, (23E)-3β-Hydroxycucurbita-6,23,25-trien-5β,19-olide 3-O-β-Dglucopyranoside: colorless needles, melting at 258–262 °C
• charantoside VIII, (23E)-3β-Hydroxy-7β,25-dimethoxycucurbita-5,23-dien-19-al 3-O-β-D-glucopyranoside: amorphous solid.

Charantosides I through VIII can be extracted from the fresh fruit with methanol and ethyl acetate.^[1]

See also

• Charantin
• Goyaglycoside
• Karaviloside
• Momordicoside

Notes and References

1. Akihisa . Toshihiro . Higo . Naoki . Tokuda . Harukuni . Ukiya . Motohiko . Akazawa . Hiroyuki . Tochigi . Yuichi . Kimura . Yumiko . Suzuki . Takashi . Nishino . Hoyoku. et al . vanc . 2007 . Cucurbitane-Type Triterpenoids from the Fruits of Momordica charantia and Their Cancer Chemopreventive Effects . Journal of Natural Products . 70 . 8. 1233–1239 . 10.1021/np068075p . 17685651 .