| Chapecó River | |
| Pushpin Map: | Brazil |
| River System: | Uruguay River |
| Source1 Location: | Santa Catarina state |
| Mouth Location: | Uruguay River |
| Mouth Coordinates: | -27.0953°N -53.0158°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Chapecó River (Portuguese, Rio Chapecó) is a river of Santa Catarina state in southeastern Brazil. It is a tributary of the Uruguay River.
The river is fed by streams rising in the Araucárias National Park, a conservation unit created in 2005.Other headwaters rise in the Mata Preta Ecological Station, a fully protected area created in 2005.The river supplies water to the municipality of Abelardo Luz, Santa Caterina. The Chapecó River Falls are one of the main attractions of the region.