Chanoclavine-I dehydrogenase explained

Chanoclavine-I dehydrogenase
Ec Number:	1.1.1.332

Chanoclavine-I dehydrogenase (easD (gene), fgaDH (gene)) is an enzyme with systematic name chanoclavine-I:NAD⁺ oxidoreductase.^{[1] [2]} This enzyme catalises the following chemical reaction

chanoclavine-I + NAD⁺

\rightleftharpoons chanoclavine-I aldehyde + NADH + H⁺

This enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.

Notes and References

1. Wallwey C, Matuschek M, Li SM . Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH . Archives of Microbiology . 192 . 2 . 127–34 . February 2010 . 20039019 . 10.1007/s00203-009-0536-1 .
2. Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM . Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae . Microbiology . 158 . Pt 6 . 1634–44 . June 2012 . 22403186 . 10.1099/mic.0.056796-0 . free .