| Chan Seng Khai | |
| Native Name Lang: | zh-my |
| Order: | 2nd Kuching South Mayor |
| Term Start: | 1 January 1997 |
| Term End: | 31 July 2005 |
| Deputy: | Mohd Amin Hassan |
| Predecessor: | Song Swee Guan |
| Successor: | Chong Ted Tsiung |
| Birth Date: | 19 July 1953 |
| Birth Place: | Kuching, Crown Colony of Sarawak |
| Citizenship: | Malaysian |
| Party: | Sarawak United Peoples' Party (SUPP) - Barisan Nasional |
Chan Seng Khai was the second mayor of Kuching South City Council since 1997. He succeeded Datuk Song Swee Guan, who was the first mayor of the city, in 1988 when Kuching was elevated to City status and partitioned into South and North. Chan is a member of Sarawak United People's Party and elected state assemblyman of the Batu Lintang area in Kuching in 1991, 1996 and 2001. In 2006, during the Sarawak's state election, he lost in his re-election bid as state assemblyman to Democratic Action Party (DAP) candidate Voon Lee Shan.