| Chalchicomula de Sesma Municipality | |
| Settlement Type: | Municipality |
| Pushpin Label Position: | above |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Puebla |
| Area Total Km2: | 364.85 |
| Population As Of: | 2005 |
| Population Total: | 43882 |
| Population Density Km2: | auto |
| Timezone: | Central Standard Time |
| Utc Offset: | -6 |
| Timezone Dst: | Central Daylight Time |
| Utc Offset Dst: | -5 |
Chalchicomula de Sesma Municipality is a municipality in the Mexican state of Puebla in south-eastern Mexico.[1]
The seat is Ciudad Serdán.
The name of the municipality is of Nahuatl origin and comes from the words chalchihuitl, meaning "turquoise," and xomulli, loosely translated as "hollow" or "nook".[2]