Chakragati mouse explained

Chakragati mouse (ckr) is an insertional transgenic mouse mutant (Mus musculus) displaying hyperactive behaviour and circling. It is also deficient in prepulse inhibition, latent inhibition^[1] and has brain abnormalities such as lateral ventricular enlargement^[2] that are typical to endophenotypic models of schizophrenia, which make it useful in screening for antipsychotic drug candidates.^[3] The mouse is currently licensed by Chakra Biotech.

External links

• Chakragati gene information on the ckr gene from Mouse Genome Informatics database

Notes and References

1. Verma V, Tan CH, Ong WY . The chakragati mouse shows deficits in prepulse inhibition of acoustic startle and latent inhibition . . 60 . 3 . 281–8 . March 2008 . 18164085 . 10.1016/j.neures.2007.11.007 . 207150983 . etal.
2. Torres G, Meeder BA, Hallas BH . Ventricular size mapping in a transgenic model of schizophrenia . Developmental Brain Research. 154. 1. 35–44. 2005 . 15617753 . 10.1016/j.devbrainres.2004.08.011. etal.
3. Dawe GS, Ratty AK . The chakragati mouse: A mouse model for rapid in vivo screening of antipsychotic drug candidates . Biotechnology Journal. 2. 11. 1344–52. 2007 . 17886239 . 10.1002/biot.200700145. 24748043 .