Chaetoxanthone Explained

Chaetoxanthones are a class of chemical compounds which are classified as xanthones. They have been isolated from marine-derived fungi in the genus Chaetomium.^[1] There are four compounds in the class that are designated as chaetoxanthones A through D.^{[1] [2]} A laboratory synthesis of (±)-chaetoxanthone B has been reported.^[3] The chaetoxanthones are under investigation as potential antimalarials.^[3]

Notes and References

1. Pontius . Alexander . Krick . Anja . Kehraus . Stefan . Brun . Reto . König . Gabriele M. . Antiprotozoal Activities of Heterocyclic-Substituted Xanthones from the Marine-Derived Fungus Chaetomium sp. . Journal of Natural Products . 1 September 2008 . 71 . 9 . 1579–1584 . 10.1021/np800294q. 18683985 .
2. 10.1016/j.cclet.2015.10.025 . Stereochemical determination of tetrahydropyran-substituted xanthones from fungus Chaetomium murorum . 2015 . Wang . Meng-Hua . Li . Li . Jiang . Tao . Wang . Xue-Wei . Sun . Bin-Da . Song . Bo . Zhang . Qiu-Bo . Jia . Hong-Mei . Ding . Gang . Zou . Zhong-Mei . Chinese Chemical Letters . 26 . 12 . 1507–1510 .
3. Lennon . Amber C. . Tallen . Sara C. . Dabire . Sadiq W. . Quach . Nhu H. . Gladen . Paul T. . Total synthesis of (±)-chaetoxanthone B . Tetrahedron Letters . October 2021 . 82 . 153390 . 10.1016/j.tetlet.2021.153390. 240556659 .