Cetadiol Explained
Cetadiol, also known as androst-5-ene-3β,16α-diol, is a drug described as a "steroid tranquilizer" which was briefly investigated as a treatment for alcoholism in the 1950s.[1] [2] [3] [4] [5] It is an androstane steroid and analogue of 5-androstenediol (androst-5-ene-3β,17β-diol) and 16α-hydroxy-DHEA (androst-5-ene-3β,16α-diol-17-one), but showed no androgenic or myotrophic activity in animal bioassays. The drug was reported in 1956 and studied until 1958.
Chemistry
See also: List of neurosteroids.
See also
Notes and References
- Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 86–.
- Book: Negwer M, Scharnow HG . Organic-chemical drugs and their synonyms: (an international survey). 2001. Wiley-VCH. 978-3-527-30247-5. 1841.
- Lemere F . New steroid hormone tranquilizing agent (cetadiol) . The American Journal of Psychiatry . 113 . 10 . 930 . April 1957 . 13402989 . 10.1176/ajp.113.10.930 .
- Campbell CH, Sleeper HG . Cetadiol (5-androstene-3 16-diol) in the treatment of hospitalized alcoholics . The American Journal of Psychiatry . 112 . 10 . 845 . April 1956 . 13302491 . 10.1176/ajp.112.10.845 .
- Wexler D, Leiderman PH, Mendelson J, Kubzansky P, Solomon P . The effect of cetadiol on delirium tremens, alcoholic hallucinosis, and alcohol withdrawal . The American Journal of Psychiatry . 114 . 10 . 935–936 . April 1958 . 13508929 . 10.1176/ajp.114.10.935 .