Centromere protein B explained

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.[1] [2] [3]

Function

Centromere protein B is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Clinical significance

Centromere protein B is a potential biomarker of small-cell lung cancer.[4]

See also

Further reading

Notes and References

  1. Web site: Entrez Gene: centromere protein B.
  2. Sugimoto K, Yata H, Himeno M . Mapping of the human CENP-B gene to chromosome 20 and the CENP-C gene to chromosome 12 by a rapid cycle DNA amplification procedure . Genomics . 17 . 1 . 240–2 . July 1993 . 8406460 . 10.1006/geno.1993.1312 .
  3. Ando S, Yang H, Nozaki N, Okazaki T, Yoda K . CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells . Molecular and Cellular Biology . 22 . 7 . 2229–41 . April 2002 . 11884609 . 133672 . 10.1128/MCB.22.7.2229-2241.2002 .
  4. Briasoulis E, Kamposioras K, Tzovaras V, Pafitanis G, Kostoula A, Mavridis A, Pavlidis N . CENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer. A case study and review of the literature . Lung Cancer . 60 . 2 . 302–6 . May 2008 . 17980453 . 10.1016/j.lungcan.2007.09.014 .