Centrin 1 Explained

Centrin-1 is a protein that in humans is encoded by the CETN1 gene.^{[1] [2]} It belongs to the centrin family of proteins.

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.

Further reading

• Tsang WY, Spektor A, Luciano DJ . CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. . Mol. Biol. Cell . 17 . 8 . 3423–34 . 2006 . 16760425 . 10.1091/mbc.E06-04-0371 . 1525247 . etal.
• Zhao ZS, Lim JP, Ng YW . The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. . Mol. Cell . 20 . 2 . 237–49 . 2006 . 16246726 . 10.1016/j.molcel.2005.08.035 . etal. free . 10536/DRO/DU:30131061 . free .
• Poole E, Strappe P, Mok HP . HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET. . Traffic . 6 . 9 . 741–55 . 2005 . 16101678 . 10.1111/j.1600-0854.2005.00312.x . etal. 36574274 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Lutz W, Lingle WL, McCormick D . Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication. . J. Biol. Chem. . 276 . 23 . 20774–80 . 2001 . 11279195 . 10.1074/jbc.M101324200 . etal. free .
• Laoukili J, Perret E, Middendorp S . Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro. . 113 . J. Cell Sci. . (Pt 8) . 1355–64 . 2000 . 8 . 10.1242/jcs.113.8.1355 . 10725219 . etal.

Notes and References

1. Errabolu R, Sanders MA, Salisbury JL . Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles . 107 . J Cell Sci . (Pt 1) . 9–16 . Jun 1994 . 10.1242/jcs.107.1.9 . 8175926 . free .
2. Web site: Entrez Gene: CETN1 centrin, EF-hand protein, 1.