Centre for Molecular Medicine and Therapeutics explained

The Centre for Molecular Medicine and Therapeutics
Staff:	Over 200 staff, including 8 Faculty, 59 trainees, and 10 administrative team members
Affiliation:	University of British Columbia, Child &Family Research Institute (CFRI), BC Children's Hospital Foundation
Street:	950 W 28th Ave
City:	Vancouver
Province:	British Columbia
Country:	Canada
Director:	Blair Leavitt

The Centre for Molecular Medicine and Therapeutics (CMMT) is part of the University of British Columbia's Faculty of Medicine. The Centre is located at the British Columbia Children's Hospital Research Institute (BCCHR) in Vancouver, British Columbia, Canada. Research at CMMT is focused on discovering genetic susceptibility to illnesses such as Huntington Disease, Type 2 diabetes and bipolar disorder.

In 2008, the founder of CMMT, Dr. Michael Hayden, was named "Researcher of the Year" by the Canada Institutes of Health Research.^[1] In 2011, he was appointed to the Order of Canada in 2011 for his contributions to Huntington's Disease research.^[2]

Principal investigators within the Centre are involved in other initiatives. Dr. Daniel Goldowitz is the Scientific Director of the Kids Brain Health network (formerly NeuroDevNet), which is a Canada Networks of Centres of Excellence.^[3] The life sciences research laboratory consists of over 200 staff, eight of whom are UBC faculty members. Four of the principal investigators at the Centre are Canada Research Chairs.^[4]

Key achievements

1999 – ABCA1 a key regulator of high-density lipoprotein in humans is discovered
2003 – LPL deficiency is cured in animal models
2004 – Open-access JASPAR database is released - a fundamental resource for studying gene regulation
2005 – Gene networks analysis algorithm published
2006 – Huntington Disease is treated in mouse model^[5]
2006 – The genetic cause of codeine-induced adverse drug reaction causing infant death is identified^[6]
2006 – A new palmitoyl transferase that promotes protein folding and transport is identified
2007 – The contribution of cholesterol to diabetes is elucidated
2007 – New software for identifying DNA changes that alter the regulation of genes is created
2007 – A severe Adverse Drug Reaction caused by normal doses of codeine is identified.
2008 – A new gene associated with bipolar disorder is identified
2008 – Genomics analysis of endosomal transport machinery is completed
2008 – Genetic Variants predictive of severe deafness in children receiving Cisplatin chemotherapy are identified
2009 – Researchers identify memantine as possible treatment for Huntington Disease^[7]
2009 - National headquarters for genetics, epigenetics data collection and analysis for the Canadian Longitudinal Study on Aging is established
2009 - Early-life poverty can "get under the skin" to program pro-inflammatory gene expression profiles^[8]
2009 - Dr. Daniel Goldowitz becomes Scientific Director of NeuroDevNet 2009-2014
2010 – Discovery of increased expression of NMDA receptors in Huntington's disease^[9]
2010 – Treatment with memantine leads to the reversal of motor and neuropathological deficits and damage in late stages of animal models of HD.
2011 - Parental stress in infancy and pre-school is associated with distinct DNA methylation patterns in adolescents^[10]
2012 - PFOND project launched online to promote the sharing of information about research, treatment, and resources for rare genetic disorders
2012 - Dr. Elizabeth Simpson leads CanEuCre, a large-scale genomic consortium, funded by Genome British Columbia in Canada (Can) and partnered with the European Commission (Eu), for the development of new Cre mouse and virus resources (Cre)
2012 - Journal of Huntington Disease (JHD) is established with Dr. Blair Leavitt as Co-Editor-in-Chief^[11]

Corporate history

CMMT's development started in the early nineties with an informal discussion between CMMT's current Director, Dr. Michael Hayden, and Merck Frosst. In 1992, a $15 million commitment over five years from Merck Frosst Canada provided the initial funding for CMMT. The following year, in 1993, UBC Board of Governors and Senate approved CMMT as the first Centre in the Faculty of Medicine. That same year, the province of British Columbia pledged $9 million to build a dedicated building for CMMT.

In 1998, the current CMMT building, located at the Child & Family Research Institute on the BC Children's and Women's Hospital site was completed and the Transgenic Core Facility was established. During 1999 and 2000, the Scientific Stores Core Facility and the DNA Sequencing Core Facility were established.

Since 2000, CMMT has further expanded its facilities and services, including the addition of a Bioanalyzer Core Facility in 2003, expansion of the Transgenic Core Facility in 2005 and the establishment of the Genotype and Gene Expression Core Facility in 2006.

Principal investigators

Dr. Elizabeth Conibear – Associate Professor, Department of Medical Genetics
Dr. Daniel Goldowitz – Canada Research Chair Tier I & Professor, Department of Medical Genetics
Dr. Michael Hayden - Founder, Professor, Department of Medical Genetics
Dr. Michael S. Kobor – Assistant Professor, Department of Medical Genetics
Dr. Blair R. Leavitt – Director, Assistant Professor, Department of Medical Genetics
Dr. Elizabeth M. Simpson – Canada Research Chair Tier II & Professor, Department of Medical Genetics
Dr. Stefan Taubert – Canada Research Chair Tier II & Assistant Professor, Department of Medical Genetics
Dr. Wyeth W. Wasserman – Professor, Department of Medical Genetics
Dr. Sara Mostafavi – Canada Research Chair Tier II & Assistant Professor, Department of Statistics, Department of Medical Genetics

Areas of research

Bioinformatics
Developmental Biology
Epigenetics
Lipid Biology
Neurobiology
Pharmacogenomics
Transgenics

External links

Notes and References

Web site: Vancouver . The . Gene mutation study earns UBC prof health researcher of the year award . Canada.com . 2008-11-20 . 2011-03-05 . https://web.archive.org/web/20110628222422/http://www.canada.com/vancouversun/news/westcoastnews/story.html?id=40652951-e9be-4604-838e-5bfa268949b6# . 2011-06-28 . dead .
Web site: The Governor General of Canada > Appointments to the Order of Canada . Gg.ca . 2010-12-30 . 2011-03-05.
Web site: NeuroDevNet . Nce-rce.gc.ca . 2011-02-04 . 2011-03-05.
Web site: Canada Research Chairs . Chairs-chaires.gc.ca . 2008-12-22 . 2011-03-05.
Web site: Cure Found For Huntington Disease In Mice Offers Hope For Treatment In Humans . Sciencedaily.com . 2006-06-16 . 2011-03-05.
17911433 . Genotypic approaches to therapy in children . September 2007. 10.1196/annals.1423.020 . 1110 . Ann. N. Y. Acad. Sci. . 177–92. Ross . C. J. . Carleton . B. . Warn . D. G. . Stenton . S. B. . Rassekh . S. R. . Hayden . M. R. .
Web site: Researchers Find Potential Treatment For Huntington's Disease . Medicalnewstoday.com . 2011-03-05.
Web site: Early-Life Experience Linked to Chronic Diseases Later in Life: UBC Research . publicaffairs.ubc.ca . 2009-07-13 . https://web.archive.org/web/20090717052820/http://www.publicaffairs.ubc.ca/media/releases/2009/mr-09-083.html# . 2009-07-17 . dead .
Web site: Huntington's Disease: Discovery Of Mechanism In Brain Cell Injury Offers New Treatment Approaches . Medicalnewstoday.com . 2011-03-05.
Web site: Stressed-out parents leave imprint on kids' genes, study says . vancouversun.com . 2011-08-01.
Web site: Journal of Huntington's Disease . iospress.nl . 2012-06-19.