Centre for Cellular and Molecular Biology explained

Centre for Cellular and Molecular Biology
Motto:Dedicated to the Nation
Established:1977
Type:Autonomous, Govt, CSIR
Director:Vinay K. Nandicoori
Address:CSIR-IICT, Uppal Rd, IICT Colony, Habsiguda, Hyderabad
City:Hyderabad
State:Telangana
Country:India
Campus:Urban, 6acres

The Centre for Cellular and Molecular Biology (Hindi: कोशिकीय एवं आण्विक जीवविज्ञान केंद्र, IAST: Kośikīya evam āṇavik jīvavijñāna kendra) or CCMB is an Indian fundamental life science research establishment located in Hyderabad that operates under the aegis of the Council of Scientific and Industrial Research. CCMB is a designated "Centre of Excellence" by the Global Molecular and Cell Biology Network, UNESCO.[1] [2]

The center collaborates with the University of Nebraska Medical Center for translational research on glaucoma.[3] In addition, the centre receives funding for specific collaborative projects from establishments outside India, such as the National Institutes of Health, Harvard Medical School and the Massachusetts Institute of Technology in the United States,[4] [5] the Imperial Cancer Research Fund and Cambridge University in the United Kingdom,[6] the India-Japan Science Council and the University of Ryukyus in Japan,[7] [8] Centre Nationale de la Recherche Scientifique and the Pasteur Institute in France and the Volkswagen Foundation in Germany.[9] [10]

History

CCMB was set up initially as a semi-autonomous Centre on 1 April 1977 with the Biochemistry Division of the then Regional Research Laboratory (presently, Indian Institute of Chemical Technology, IICT) in Habsiguda, Hyderabad forming its nucleus and Dr P M Bhargava heading the new Centre. Earlier, the Governing Board of the Council of Scientific and Industrial Research (CSIR) New Delhi, the apex body which constituted 44 research institutions (now 38) in the country, approved the proposal in 1976 to establish such a Centre in view of the importance of research in the frontier and multi-disciplinary areas of modern biology. During 1981–82, the CCMB was accorded the status of a full-fledged national laboratory with its own Executive Committee and Scientific Advisory Council. With major expansion plans, it was decided to relocate the centre to a spacious campus.

Former directors

The list of former directors.[11] [12]

NameFromTo
April 1977 February 1990
Sharat Chandra March 1990 May 1992
May 1992 May 1998
May 1998 July 2009
July 2009 January 2016
May 2016 Apr 2021

Research

The ongoing research programmes at the CCMB are in three major categories – high quality basic research in the frontier areas of modern biology, research relevant to societal needs, and application-oriented research towards commercialization. These include the areas of evolution & development, gene regulation in prokaryotes and eukaryotes, host-parasite interactions, membrane biology, protein structure, stem cell biology, neurobiology, bioinformatics, functional genomics, ecology and ecosystems.

Annexe I – LaCONES

The Laboratory for Conservation of Endangered Species is an annexe with the aim to conserve the Indian wildlife by using modern biological techniques and assisted reproductive technologies. It has worked extensively with various departments of the Government of India to curb wildlife crime. They have helped identify the source of animal meat in cases of doubt, sources of smuggled animals, and study stress among wild animals via non-invasive measures. They have helped the Directorate of Aerospace Safety to identify the reason on bird hits, and help them in canopy engineering of their airports. They host the National Wildlife Genetic Resource Bank with currently 250 genetic samples of animals, collected from zoos across the country. They can contain up to 17,000 samples. In the past few years, they have worked with the Nehru Zoological Park, Hyderabad to protect the mouse deer from extinction. In August 2018, they started with the phased release of these animals into their original habitats of Amrabad Tiger Reserve.

Annexe II – Medical Biotechnology Complex

CCMB carries out molecular diagnostic tests for 30 genetic disorders and wildlife forensics its medical biotechnology complex, also known as Innovation Hub (iHUB). It also hosts the Atal Incubation Centre-CCMB (AIC-CCMB) to support early stage life science startups. This initiative is supported by NITI Aayog and Atal Innovation Mission. They have been supporting startups working in drug discovery, drug repurposing, vaccine development, diagnostics, nutrition and nanomaterial development. They now host a Meity Startup Hub to incubate startups that look into big data in life sciences/healthcare sector.

PhD program in CCMB

To join CCMB's PhD program one needs to apply for their application test followed by interviews. Most students join in with their own fellowships from CSIR, UGC, DBT, ICMR, or DST. There are two rounds of intake each year, one in January (interviews are held in December), and the other in July (interviews are held in June).

Most alumni from CCMB's PhD program have continued in academia or joined the life science industry in India and abroad. They are present in premier research and educational institutes of India including IISc, IISERs, NISER and IITs and many central and state universities.

Collaborations

The centre actively collaborates with life scientists in India and abroad. The list of national collaborations run with premier research institutes as well as universities. This list of present and past collaborations includes Tata Institute of Fundamental Research, inStem, ICAR-Indian Institute of Rice Research, University of Hyderabad, CSIR-Institute of Genomics and Integrative Biology, ICAR-National Research Centre on Meat among multiple others.

The centre has collaborated with the University of Nebraska Medical Center for translational research on glaucoma[13] In addition, the centre receives funding for specific collaborative projects from establishments outside India, such as the National Institutes of Health, Harvard Medical School and Massachusetts Institute of Technology in United States,[14] [15] the Imperial Cancer Research Fund and Cambridge University in United Kingdom,[16] the India-Japan Science Council and the University of Ryukyus in Japan,[17] Centre Nationale de la Recherche Scientifique and the Pasteur Institute in France and the Volkswagen Foundation in Germany.[18] [19]

Technological achievements

Societal Relevance of CCMB

Awards and honours

In recognition for its contribution to modern biology, CCMB has been chosen as a Centre of Excellence by UNESCO Global Network for Molecular and Cell Biology (MCBN), and has been designated as a South Centre for Excellence for Research and Training by the Third World Academy of Sciences TWAS, Italy. Many prestigious international and national awards have come to CCMB including the CSIR Technology Award (four times) and FICCI Award for outstanding achievements in Science & Technology.

CCMB scientists have 1 Padma Bhushan, 4 Padma Shri, 3 Infosys Prize, 11 Shanti Swarup Bhatnagar awardees along with 14 JC Bose, 3 Third World Academy of Sciences, 24 Indian Academy of Sciences, 20 National Academy of Sciences, and 21 Indian National Science Academy fellows. 10 CCMB scientists have become Directors of educational or research institutes and 6 Vice-Chancellors or Deans in universities or educational institutes of India.

Reaching CCMB

The main campus of CCMB is located on the inner ring road of Hyderabad, connecting the areas Secunderabad and Uppal. CCMB can be reached very conveniently by the city road transport buses and the new Hyderabad metro at Habsiguda.

See also

Notes and references

17.421°N 78.541°W

Notes and References

  1. News: CCMB develops DNA test to identify animal species . Business Line. Chennai . 2003-04-30 . 2012-08-22 . 20 August 2012 . https://web.archive.org/web/20120820030129/http://www.thehindubusinessline.in/2003/04/30/stories/2003043001921900.htm . dead .
  2. News: Times News Network. CCMB identifies milk gene . https://web.archive.org/web/20110811025557/http://articles.timesofindia.indiatimes.com/2006-05-10/science/27823408_1_ccmb-scientists-milk-mice-strain . dead . 2011-08-11 . 2006-05-10 . . 2012-08-22.
  3. Glaucoma Research . 2012-12-01.
  4. News: Harvard School of Public Health » HSPH News » New research reveals the ancestral populations of India and their relationships to modern groups . News . Hsph.harvard.edu . 2009-09-23 . 2013-04-16.
  5. Web site: caste system existed from 'Founder' race: CCMB-Harvard-MIT study . News.webindia123.com . 2009-09-24 . 2013-04-16.
  6. Web site: Modern man went into the world via India . https://web.archive.org/web/20101229105041/http://epaper.timesofindia.com/Repository/ml.asp?Ref=TU1JUi8yMDA5LzAxLzIxI0FyMDE1MDA=&Mode=HTML&Locale=english-skin-custom . dead . 29 December 2010 . The Times of India . 2009-01-21 . 2013-04-16.
  7. http://cdn.intechopen.com/pdfs/20874/InTech-Japanese_encephalitis_an_emerging_and_spreading_arbovirosis.pdf
  8. HTLV-1 Tax Specific CD8+ T Cells Express Low Levels of Tim-3 in HTLV-1 Infection: Implications for Progression to Neurological Complications . 3082508 . 21541358 . 10.1371/journal.pntd.0001030 . 5 . 2011 . PLOS Negl Trop Dis . e1030 . Ndhlovu . LC . Leal . FE . Hasenkrug . AM . Jha . AR . Carvalho . KI . Eccles-James . IG . Bruno . FR . Vieira . RG . York . VA . Chew . GM . Jones . RB . Tanaka . Y . Neto . WK . Sanabani . SS . Ostrowski . MA . Segurado . AC . Nixon . DF . Kallas . EG. 4 . free .
  9. Web site: Research > Research Partners . Ccmb.res.in . 2013-04-16 . dead . https://web.archive.org/web/20131218041613/http://www.ccmb.res.in/about_associations.html . 2013-12-18 .
  10. News: Education Plus : Opening new vistas of research in biology . The Hindu . 2011-05-31 . 2013-04-16 . Chennai, India . 29 June 2013 . https://archive.today/20130629115341/http://www.hindu.com/edu/2011/05/31/stories/2011053150050200.htm . dead .
  11. Web site: About CCMB > Organisation Structure . 2014-02-23 . dead . https://web.archive.org/web/20120722014557/http://ccmb.res.in/about_people1.html . 2012-07-22 .
  12. Web site: Dr Rakesh Mishra appointed as the new Director of CCMB, Hyderabad . Bio Voice . 21 May 2016 . 10 October 2016.
  13. Glaucoma Research. 2012-12-01.
  14. Web site: Harvard School of Public Health » HSPH News » New research reveals the ancestral populations of India and their relationships to modern groups. 2009-09-23. Hsph.harvard.edu. 2013-04-16.
  15. Web site: caste system existed from 'Founder' race: CCMB-Harvard-MIT study. 2009-09-24. News.webindia123.com. 2013-04-16.
  16. Web site: Modern man went into the world via India. https://web.archive.org/web/20101229105041/http://epaper.timesofindia.com/Repository/ml.asp?Ref=TU1JUi8yMDA5LzAxLzIxI0FyMDE1MDA=&Mode=HTML&Locale=english-skin-custom. dead. 29 December 2010. 2009-01-21. The Times of India. 2013-04-16.
  17. Ndhlovu. LC. Leal. FE. Hasenkrug. AM. Jha. AR. Carvalho. KI. Eccles-James. IG. Bruno. FR. Vieira. RG. York. VA. Chew. GM. Jones. RB. 2011. HTLV-1 Tax Specific CD8+ T Cells Express Low Levels of Tim-3 in HTLV-1 Infection: Implications for Progression to Neurological Complications. PLOS Negl Trop Dis. 5. e1030. 10.1371/journal.pntd.0001030. 3082508. 21541358. MA. Kallas. DF. Nixon. AC. Segurado. Sanabani. Ostrowski. SS. WK. Neto. Y. Tanaka. EG. 4 . free .
  18. Web site: Research > Research Partners. Ccmb.res.in. dead. https://web.archive.org/web/20131218041613/http://www.ccmb.res.in/about_associations.html. 2013-12-18. 2013-04-16.
  19. News: Education Plus : Opening new vistas of research in biology. https://archive.today/20130629115341/http://www.hindu.com/edu/2011/05/31/stories/2011053150050200.htm. dead. 2013-06-29. 2011-05-31. 2013-04-16. The Hindu. Chennai, India.
  20. http://www.sanger.ac.uk/about/press/2009/090118.html The worst luck in the world? – Wellcome Trust Sanger Institute
  21. News: Scientists complete work on gene knockout technology. https://archive.today/20130629111128/http://www.hindu.com/2006/05/10/stories/2006051009080700.htm. dead. 2013-06-29. 2006-05-10. The Hindu. Chennai, India.
  22. http://www.dnaindia.com/india/1020582/report-ccmb-implements-artificial-insemination-in-deer CCMB implements artificial insemination in deer – India – DNA
  23. News: CCMB scientists develop new drug assay system. https://archive.today/20130629133154/http://articles.timesofindia.indiatimes.com/2001-11-03/science/27238017_1_ccmb-drosophila-system-show-anti-cancer-properties. dead. 2013-06-29. The Times of India. 2001-11-03.
  24. News: DNA fingerprinting has come a long way, says Lalji Singh. 2013-02-17. The Hindu. Chennai, India.
  25. News: CCMB scientists develop new method to test cancer. https://archive.today/20130629121934/http://articles.timesofindia.indiatimes.com/2001-11-04/hyderabad/27237029_1_ccmb-colon-cancer. dead. 2013-06-29. The Times of India. 2001-11-04.
  26. News: CCMB grows pest-resistant Samba Masuri rice strain. https://archive.today/20130629123520/http://articles.timesofindia.indiatimes.com/2011-11-29/hyderabad/30453881_1_samba-masuri-ccmb-farmers. dead. 2013-06-29. The Times of India. 2011-11-29.
  27. News: Mallikarjun. Y.. New found bacteria get Indian nomenclatures. 2011-11-13. The Hindu. Chennai, India.
  28. https://web.archive.org/web/20130608154009/http://newindianexpress.com/cities/hyderabad/DNA-CCMB-scientists-achieve-breakthrough/2013/05/16/article1591902.ece DNA: CCMB scientists achieve breakthrough – The New Indian Express
  29. http://www.jagranjosh.com/current-affairs/scientists-from-ccmb-and-aig-discovered-gene-causing-chronic-pancreatitis-1376893389-1 Scientists from CCMB and AIG Discovered Gene Causing Chronic Pancreatitis

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