| Centralia High School | |
| Location: | 2100 East Calumet Centralia, Illinois |
| Country: | USA |
| District: | Centralia High School District 200 |
| Principal: | Reid Shipley |
| Faculty: | 67.05 (on FTE basis) |
| Ratio: | 13.15 |
| Enrollment: | 882 (2018–19)[1] |
| Type: | Public |
| Grades: | 9 to 12 |
| Conference: | South 7 |
| Mascot: | Orphans/Orphan Annies |
| Colors: | Cardinal and white [2] |
Centralia High School is a public high school located in Centralia, Illinois, United States. The mascot of the school's athletic teams is the Orphans (boys) and the Annies (girls).