Central chromatolysis explained

Central chromatolysis is a histopathologic change seen in the cell body of a neuron, where the chromatin and cell nucleus are pushed to the cell periphery, in response to axonal injury.^{[1] [2]} This response is associated with increased protein synthesis to accommodate for axonal sprouting.In addition to traumatic injuries, central chromatolysis may be caused by vitamin deficiency (pellagra^[3]).

See also

• Motor neuron

External links

• Neurocytology and Basic Reactions (neuropathologyweb.org)

Notes and References

1. Neuropathology - Basic Reactions. University of Vermont. URL: http://www.uvm.edu/~jkessler/NP/neuropbr.htm . Accessed on: 1 January 2011.
2. Holland GR . Experimental trigeminal nerve injury . Crit. Rev. Oral Biol. Med. . 7 . 3 . 237–58 . 1996 . 8909880 .
3. Piercecchi-Marti MD, Pélissier-Alicot AL, Leonetti G, Tervé JP, Cianfarani F, Pellissier JF . Pellagra: a rare disease observed in a victim of mental and physical abuse . Am J Forensic Med Pathol . 25 . 4 . 342–4 . December 2004 . 15577526 . 10.1097/01.paf.0000136589.28903.e5.