Centpropazine Explained
| Routes Of Administration: | Oral |
| Cas Number: | 91315-34-3 |
| Pubchem: | 118176 |
| Chemspiderid: | 105612 |
| Unii: | R5YPG9LA47 |
| Chembl: | 4303166 |
| Synonyms: | CPZ; CTZ |
| Iupac Name: | 1-[4-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]phenyl]propan-1-one |
| C: | 22 |
| H: | 28 |
| N: | 2 |
| O: | 3 |
| Smiles: | CCC(=O)C1=CC=C(C=C1)OCC(CN2CCN(CC2)C3=CC=CC=C3)O |
| Stdinchi: | 1S/C22H28N2O3/c1-2-22(26)18-8-10-21(11-9-18)27-17-20(25)16-23-12-14-24(15-13-23)19-6-4-3-5-7-19/h3-11,20,25H,2,12-17H2,1H3 |
| Stdinchikey: | ZQPXSRTZFYHSFB-UHFFFAOYSA-N |
Centpropazine (CPZ, CTZ) is an experimental antidepressant which was under development for the treatment major depressive disorder in India but was never marketed.[1] [2] [3] It is described as having imipramine-like clinical effects, reversing reserpine-induced effects in animals, and potentiating amphetamine-induced effects in animals. The mechanism of action of centpropazine is unknown.[4] The drug reached phase 3 clinical trials prior to the discontinuation of its development. It was first described in the scientific literature by 1980.[5]
Notes and References
- Web site: Centpropazine . AdisInsight . Springer Nature Switzerland AG . 10 December 2013 . 27 September 2024.
- Avasthi A, Grover S, Aggarwal M . Research on antidepressants in India . Indian Journal of Psychiatry . 52 . Suppl 1 . S341–S354 . January 2010 . 21836704 . 10.4103/0019-5545.69263 . free . 3146188 .
- Book: Kaiser C, Bondinell WE . Annual Reports in Medicinal Chemistry . Chapter 1. Antidepressants . Elsevier . 1981 . 16 . 978-0-12-040516-9 . 0065-7743 . 10.1016/s0065-7743(08)61268-3 . 1–10.
- shrafuzzaman M, Ji SH, Ahn H, Chung HW, Choi D, Park JJ, Go M, Pyo JI, Shafioul AS, Lee DH, Chi SG . Identification of 1-phenoxy-3-(piperazin-1-yl)propan-2-ol derivatives as novel triple reuptake inhibitors . Bulletin of the Korean Chemical Society . Wiley . 44 . 7 . 29 March 2023 . 1229-5949 . 10.1002/bkcs.12693 . free . 596–599 .
- Singh H, Chawla AS, Kapoor VK . Medicinal chemistry research in India . Progress in Medicinal Chemistry . 22 . 243–266 . 1985 . 2873624 . 10.1016/s0079-6468(08)70232-7 . 978-0-444-80668-0 .
