SERPINA9 explained

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1.^[1] Serpin A9 is a member of the serpin family of serine protease inhibitors.

Function

The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.^{[2] [3] [4]}

Further reading

• Luke MM, O'Meara ES, Rowland CM, etal . Gene variants associated with ischemic stroke: the cardiovascular health study. . Stroke . 40 . 2 . 363–8 . 2009 . 19023099 . 2881155 . 10.1161/STROKEAHA.108.521328 .
• Frazer JK, Jackson DG, Gaillard JP, etal . Identification of centerin: a novel human germinal center B cell-restricted serpin. . Eur. J. Immunol. . 30 . 10 . 3039–48 . 2000 . 11069088 . 10.1002/1521-4141(200010)30:10<3039::AID-IMMU3039>3.0.CO;2-H . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 .
• Morrison AC, Bare LA, Luke MM, etal . Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study. . Cerebrovasc. Dis. . 26 . 4 . 420–4 . 2008 . 18799872 . 2662496 . 10.1159/000155637 .
• Shiffman D, O'Meara ES, Bare LA, etal . Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. . Arterioscler. Thromb. Vasc. Biol. . 28 . 1 . 173–9 . 2008 . 17975119 . 2636623 . 10.1161/ATVBAHA.107.153981 .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 403697 . 10.1101/gr.1293003 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Montes-Moreno S, Roncador G, Maestre L, etal . Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas. . Blood . 111 . 1 . 351–8 . 2008 . 17898315 . 10.1182/blood-2007-06-094151 . free .
• Pan Z, Shen Y, Du C, etal . Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells. . Am. J. Pathol. . 163 . 1 . 135–44 . 2003 . 12819018 . 1868163 . 10.1016/S0002-9440(10)63637-1 .
• Namciu SJ, Friedman RD, Marsden MD, etal . Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1 . Mamm. Genome . 15 . 3 . 162–78 . 2004 . 15014966 . 10.1007/s00335-003-2311-y . 8594824 .

External links

• The MEROPS online database for peptidases and their inhibitors: I04.082

Notes and References

1. Web site: Entrez Gene: SERPINA9 .
2. Paterson MA, Horvath AJ, Pike RN, Coughlin PB . Molecular characterization of centerin, a germinal centre cell serpin . Biochem. J. . 405 . 3 . 489–94 . August 2007 . 17447896 . 2267310 . 10.1042/BJ20070174 .
3. Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA . Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas . Blood . 111 . 1 . 351–8 . January 2008 . 17898315 . 10.1182/blood-2007-06-094151 . free .
4. Paterson MA, Hosking PS, Coughlin PB . Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas . Am. J. Clin. Pathol. . 130 . 1 . 117–26 . July 2008 . 18550480 . 10.1309/9QKE68QU7B825A3U . free .