Centaurin, alpha 1 explained

Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ADAP1 gene.^{[1] [2]}

Interactions

Centaurin, alpha 1 has been shown to interact with:

• Casein kinase 1, alpha 1^{[3] [4]}
• Nucleolin,^[5]
• P110α,
• PRKCI,
• Protein kinase D1,^[6] and
• Protein kinase Mζ.^[6]

Further reading

• Venkateswarlu K, Cullen PJ . Molecular cloning and functional characterization of a human homologue of centaurin-alpha . Biochemical and Biophysical Research Communications . 262 . 1 . 237–44 . Aug 1999 . 10448098 . 10.1006/bbrc.1999.1065 .
• Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A . Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins . The Journal of Biological Chemistry . 276 . 22 . 18757–64 . Jun 2001 . 11278595 . 10.1074/jbc.M010005200 . free .
• Sedehizade F, Hanck T, Stricker R, Horstmayer A, Bernstein HG, Reiser G . Cellular expression and subcellular localization of the human Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in neuronal cells . Brain Research. Molecular Brain Research . 99 . 1 . 1–11 . Feb 2002 . 11869802 . 10.1016/S0169-328X(01)00335-7 .
• Whitley P, Gibbard AM, Koumanov F, Oldfield S, Kilgour EE, Prestwich GD, Holman GD . Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle . European Journal of Cell Biology . 81 . 4 . 222–30 . Apr 2002 . 12018390 . 10.1078/0171-9335-00242 .
• Reiser G, Bernstein HG . Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha . NeuroReport . 13 . 18 . 2417–9 . Dec 2002 . 12499840 . 10.1097/00001756-200212200-00008 . 24499944 .
• Dubois T, Zemlickova E, Howell S, Aitken A . Centaurin-alpha 1 associates in vitro and in vivo with nucleolin . Biochemical and Biophysical Research Communications . 301 . 2 . 502–8 . Feb 2003 . 12565890 . 10.1016/S0006-291X(02)03010-3 .
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S . Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways . Oncogene . 22 . 21 . 3307–18 . May 2003 . 12761501 . 10.1038/sj.onc.1206406 . 38880905 .
• Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A . Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C . Biochemical and Biophysical Research Communications . 307 . 3 . 459–65 . Aug 2003 . 12893243 . 10.1016/S0006-291X(03)01187-2 .
• Venkateswarlu K, Brandom KG, Lawrence JL . Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization . The Journal of Biological Chemistry . 279 . 8 . 6205–8 . Feb 2004 . 14625293 . 10.1074/jbc.C300482200 . 34971745 . free .
• Hanck T, Stricker R, Sedehizade F, Reiser G . Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins . Journal of Neurochemistry . 88 . 2 . 326–36 . Jan 2004 . 14690521 . 10.1046/j.1471-4159.2003.02143.x . 19363530 .
• Reiser G, Bernstein HG . Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin . NeuroReport . 15 . 1 . 147–8 . Jan 2004 . 15106847 . 10.1097/00001756-200401190-00028 . 23980496 .
• Thacker E, Kearns B, Chapman C, Hammond J, Howell A, Theibert A . The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton . European Journal of Cell Biology . 83 . 10 . 541–54 . Oct 2004 . 15679100 . 10.1078/0171-9335-00416 .
• Lawrence J, Mundell SJ, Yun H, Kelly E, Venkateswarlu K . Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization . Molecular Pharmacology . 67 . 6 . 1822–8 . Jun 2005 . 15778454 . 10.1124/mol.105.011338 . 85844075 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Hayashi H, Matsuzaki O, Muramatsu S, Tsuchiya Y, Harada T, Suzuki Y, Sugano S, Matsuda A, Nishida E . Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases . The Journal of Biological Chemistry . 281 . 3 . 1332–7 . Jan 2006 . 16287813 . 10.1074/jbc.M505905200 . free .
• Sedehizade F, von Klot C, Hanck T, Reiser G . p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor . Neurochemical Research . 30 . 10 . 1319–30 . Oct 2005 . 16341594 . 10.1007/s11064-005-8804-1 . 12972048 .

Notes and References

1. Venkateswarlu K, Oatey PB, Tavaré JM, Jackson TR, Cullen PJ . Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1 . The Biochemical Journal . 340 . 2 . 359–63 . Jun 1999 . 10333475 . 1220257 . 10.1042/0264-6021:3400359 .
2. Web site: Entrez Gene: CENTA1 centaurin, alpha 1.
3. Dubois T, Howell S, Zemlickova E, Aitken A . Identification of casein kinase Ialpha interacting protein partners . FEBS Letters . 517 . 1–3 . 167–71 . Apr 2002 . 12062430 . 10.1016/s0014-5793(02)02614-5. 84792445 . free .
4. Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A . Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins . The Journal of Biological Chemistry . 276 . 22 . 18757–64 . Jun 2001 . 11278595 . 10.1074/jbc.M010005200 . free .
5. Dubois T, Zemlickova E, Howell S, Aitken A . Centaurin-alpha 1 associates in vitro and in vivo with nucleolin . Biochemical and Biophysical Research Communications . 301 . 2 . 502–8 . Feb 2003 . 12565890 . 10.1016/s0006-291x(02)03010-3.
6. Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A . Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C . Biochemical and Biophysical Research Communications . 307 . 3 . 459–65 . Aug 2003 . 12893243 . 10.1016/s0006-291x(03)01187-2.