Cell adhesion molecule 1 explained

Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.^{[1] [2]}

Interactions

Cell adhesion molecule 1 has been shown to interact with EPB41L3.^[3]

Association studies

Genome-wide association studies identified an association between body mass index and two loci near the CADM1 and CADM2 gene.^[4] Experimental results of another study showed that obese mice had an over expression of both CADM1 and CADM2 genes, and that loss of CADM1 protected mice from obesity, promoting a negative energy balance and weight loss.^[5] Furthermore, a 2019 GWAS study revealed an association between Anorexia nervosa and CADM1.^[6] In the brain, this genes mediate synaptic assembly, and mutations in CADM1 are also associated with Autistic spectrum disorder. ^[7]

See also

• Cell adhesion molecule
• Nectin

Further reading

• Watabe K, Ito A, Koma YI, Kitamura Y . IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function. . Histol. Histopathol. . 18 . 4 . 1321–9 . 2004 . 12973698 .
• Kuramochi M . TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer . Nat. Genet. . 27 . 4 . 427–30 . 2001 . 11279526 . 10.1038/86934 . vanc. Fukuhara H . Nobukuni T . 3 . Kanbe . Takamasa . Maruyama . Tomoko . Ghosh . Hara P. . Pletcher . Mathew . Isomura . Minoru . Onizuka . Masataka . 2241/1028 . 9773234 . free .
• Masuda M . The tumor suppressor protein TSLC1 is involved in cell-cell adhesion . J. Biol. Chem. . 277 . 34 . 31014–9 . 2002 . 12050160 . 10.1074/jbc.M203620200 . vanc. Yageta M . Fukuhara H . 3 . Kuramochi . M . Maruyama . T . Nomoto . A . Murakami . Y . free .
• Fukuhara H . Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer . Jpn. J. Cancer Res. . 93 . 6 . 605–9 . 2003 . 12079507 . 5927049 . 10.1111/j.1349-7006.2002.tb01297.x. vanc. Kuramochi M . Fukami T . 3 . Kasahara . K . Furuhata . M . Nobukuni . T . Maruyama . T . Isogai . K . Sekiya . T .
• Allinen M . Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylation . Genes Chromosomes Cancer . 34 . 4 . 384–9 . 2002 . 12112527 . 10.1002/gcc.10079 . vanc. Peri L . Kujala S . 3 . Lahti-Domenici . Jaana . Outila . Kati . Karppinen . Sanna-Maria . Launonen . Virpi . Winqvist . Robert . 396701 .
• Biederer T . SynCAM, a synaptic adhesion molecule that drives synapse assembly . Science . 297 . 5586 . 1525–31 . 2002 . 12202822 . 10.1126/science.1072356 . vanc. Sara Y . Mozhayeva M . 3 . Atasoy . D . Liu . X . Kavalali . ET . Südhof . TC . 2002Sci...297.1525B. 14529914 .
• Yageta M . Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer . Cancer Res. . 62 . 18 . 5129–33 . 2002 . 12234973 . vanc. Kuramochi M . Masuda M . 3 . Fukami . T . Fukuhara . H . Maruyama . T . Shibuya . M . Murakami . Y .
• Jansen M . Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs . Cancer Biol. Ther. . 1 . 3 . 293–6 . 2003 . 12432281 . 10.4161/cbt.84. vanc. Fukushima N . Rosty C . 3 . Walter . K . Altink . R . Heek . TV . Hruban . R . Offerhaus . JG . Goggins . M . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Honda T . Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines . Jpn. J. Cancer Res. . 93 . 8 . 857–60 . 2003 . 12716461 . 5927103 . 10.1111/j.1349-7006.2002.tb01329.x. vanc. Tamura G . Waki T . 3 . Jin . Z . Sato . K . Motoyama . T . Kawata . S . Kimura . W . Nishizuka . S .
• Shingai T . Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells . J. Biol. Chem. . 278 . 37 . 35421–7 . 2003 . 12826663 . 10.1074/jbc.M305387200 . vanc. Ikeda W . Kakunaga S . 3 . Morimoto . K . Takekuni . K . Itoh . S . Satoh . K . Takeuchi . M . Imai . T . free .
• Ito A . Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma . Lab. Invest. . 83 . 8 . 1175–83 . 2003 . 12920246 . 10.1097/01.LAB.0000081391.28136.80 . vanc. Okada M . Uchino K . 3 . Wakayama . T . Koma . Y . Iseki . S . Tsubota . N . Okita . Y . Kitamura . Y . free .
• Fukami T . Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines . Int. J. Cancer . 107 . 1 . 53–9 . 2003 . 12925956 . 10.1002/ijc.11348 . vanc. Fukuhara H . Kuramochi M . 3 . Maruyama . Tomoko . Isogai . Kana . Sakamoto . Michiie . Takamoto . Shinichi . Murakami . Yoshinori . 26363429 . free .
• Uchino K . Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung . Cancer . 98 . 5 . 1002–7 . 2003 . 12942568 . 10.1002/cncr.11599 . vanc. Ito A . Wakayama T . 3 . Koma . Yu-Ichiro . Okada . Tomoyo . Ohbayashi . Chiho . Iseki . Shoichi . Kitamura . Yukihiko . Tsubota . Noriaki . 35242800 . free .
• Clark HF . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . vanc. Gurney AL . Abaya E . 3 . Baker . K . Baldwin . D . Brush . J . Chen . J . Chow . B . Chui . C .
• Fukuhara H . Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg . Oncogene . 22 . 40 . 6160–5 . 2003 . 13679854 . 10.1038/sj.onc.1206744 . vanc. Masuda M . Yageta M . 3 . Fukami . Takeshi . Kuramochi . Masami . Maruyama . Tomoko . Kitamura . Tadaichi . Murakami . Yoshinori . free .
• Ito T . Involvement of TSLC1 in progression of esophageal squamous cell carcinoma . Cancer Res. . 63 . 19 . 6320–6 . 2003 . 14559819 . vanc. Shimada Y . Hashimoto Y . 3 . Kaganoi . J . Kan . T . Watanabe . G . Murakami . Y . Imamura . M .
• Mao X . The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer . Cancer Res. . 63 . 22 . 7979–85 . 2004 . 14633730 . vanc. Seidlitz E . Ghosh K . 3 . Murakami . Y . Ghosh . HP .

Notes and References

1. Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M . A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2 . Genomics . 62 . 2 . 139–46 . Feb 2000 . 10610705 . 10.1006/geno.1999.6001 .
2. Web site: Entrez Gene: CADM1 cell adhesion molecule 1.
3. Yageta . Mika . Kuramochi Masami. Masuda Mari. Fukami Takeshi. Fukuhara Hiroshi. Maruyama Tomoko. Shibuya Masabumi. Murakami Yoshinori . Sep 2002 . Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer . Cancer Res. . 62 . 18 . 5129–33 . 0008-5472. 12234973 .
4. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, etal . Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index . Nature Genetics . 42 . 11 . 937–48 . November 2010 . 20935630 . 3014648 . 10.1038/ng.686 .
5. Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, etal . Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1 . Nature Neuroscience . 20 . 8 . 1096–1103 . August 2017 . 28628102 . 5533218 . 10.1038/nn.4590 .
6. Watson HJ, Yilmaz Z, Thornton LM, Hübel C, Coleman JR, Gaspar HA, etal . Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa . Nature Genetics . 51 . 8 . 1207–1214 . August 2019 . 31308545 . 6779477 . 10.1038/s41588-019-0439-2 .
7. Fujita E, Tanabe Y, Imhof BA, Momoi MY, Momoi T . A complex of synaptic adhesion molecule CADM1, a molecule related to autism spectrum disorder, with MUPP1 in the cerebellum . J Neurochem . 123 . 5 . 886–94 . December 2012 . 22994563 . 10.1111/jnc.12022. free.