Cell Ontology Explained

The Cell Ontology is an ontology that aims at capturing the diversity of cell types in animals.^[1] It is part of the Open Biomedical and Biological Ontologies (OBO) Foundry. ^[2] The Cell Ontology identifiers and organizational structure are used to annotate data at the level of cell types, for example in single-cell RNA-seq studies.^[3] It is one important resource in the construction of the Human Cell Atlas. ^[4]

The Cell Ontology was first described in an academic article in 2005. ^[5]

See also

• Gene ontology
• OBO Foundry

External links

• Cell Ontology GitHub page

Notes and References

1. Diehl AD, Meehan TF, Bradford YM, Brush MH, Dahdul WM, Dougall DS, He Y, Osumi-Sutherland D, Ruttenberg A, Sarntivijai S, Van Slyke CE, Vasilevsky NA, Haendel MA, Blake JA, Mungall CJ . 6 . The Cell Ontology 2016: enhanced content, modularization, and ontology interoperability . Journal of Biomedical Semantics . 7 . 1 . 44 . July 2016 . 27377652 . 4932724 . 10.1186/s13326-016-0088-7 . free .
2. Smith B, Ashburner M, Rosse C, Bard J, Bug W, Ceusters W, Goldberg LJ, Eilbeck K, Ireland A, Mungall CJ, Leontis N, Rocca-Serra P, Ruttenberg A, Sansone SA, Scheuermann RH, Shah N, Whetzel PL, Lewis S . 6 . The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration . Nature Biotechnology . 25 . 11 . 1251–5 . November 2007 . 17989687 . 10.1038/nbt1346 . 2814061 .
3. Bernstein MN, Ma Z, Gleicher M, Dewey CN . CellO: comprehensive and hierarchical cell type classification of human cells with the Cell Ontology . iScience . 24 . 1 . 101913 . January 2021 . 33364592 . 10.1016/j.isci.2020.101913. 10.1101/634097 . 7753962 . 2021iSci...24j1913B .
4. Osumi-Sutherland. David. Xu. Chuan. Keays. Maria C.. Kharchenko. Peter V.. Regev. Aviv. Lein. Ed S.. Teichmann. Sarah. 2021-06-28. Cell type ontologies of the Human Cell Atlas. Nature Cell Biology . 23 . 11 . 1129–1135 . 10.1038/s41556-021-00787-7 . 2106.14443 . 235658396 . English.
5. Bard. Jonathan. Rhee. Seung Y.. Ashburner. Michael. 2005. An ontology for cell types. Genome Biology. en. 6. 2. R21. 10.1186/gb-2005-6-2-r21. 15693950. 551541 . free .