Cell-cycle nonspecific antineoplastic agents explained

Cell-cycle nonspecific antineoplastic agents (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or any phases of the cell cycle.^[1]

Alkylating antineoplastic agent and anthracyclins are two examples.

Further reading

• Alberts DS, Golde DW . DNA synthesis in multiple myeloma cells following cell cycle-nonspecific chemotherapy . Cancer Res. . 34 . 11 . 2911–4 . November 1974 . 4424360 .
• Ozawa S, Sugiyama Y, Mitsuhashi Y, Kobayashi T, Inaba M . Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product . Cancer Chemother. Pharmacol. . 21 . 3 . 185–90 . 1988 . 3129204 . 10.1007/bf00262767.

Notes and References

1. Web site: Chemotherapy: The Basics . OncoLink . 2008-12-17 . dead . https://web.archive.org/web/20070314053614/http://cancer.med.upenn.edu/treatment/article.cfm?c=2&s=9&id=319 . 2007-03-14 .