Celine Marmion Explained
Celine J. Marmion is a Professor of Chemistry at the Royal College of Surgeons in Ireland and President of the Institute of Chemistry of Ireland. She is a Fellow of the Royal Society of Chemistry and the Institute of Chemistry of Ireland. Marmion is involved with the design of new chemotherapeutic drugs.
Early life and education
Marmion earned her doctoral degree at the University of Surrey in 1994.[1] Her PhD research involved investigations into vanadium complexes and nitrogen fixation. In 1994 Marmion was appointed as a lecturer at St Mary's University, Twickenham, where she worked until 1995.[2] She returned to study in 1995, and earned a Postgraduate Certificate in Education (PGCE) at Kingston University.[3]
Research and career
In 1997 Marmion joined Royal College of Surgeons in Ireland as a lecturer in the Department of Chemistry. She was promoted to Associate Professor in 2013 and Professor in 2018. Her research considers the design of metal-based chemotherapeutic drugs. In particular, this has included the design of targeted PtIV prodrugs.[4] [5] Immunodeficient cancer patients are at risk of developing infections, which occasionally require antimicrobial prophylaxis. To better serve these patients Marmion developed a family of metallo-antibiotics, based on a Cu-N,N-framework, which can bind to DNA, has DNA oxidant properties and has antiproliferative and antimicrobial properties.[6] Her research has been supported by the Science Foundation Ireland (SFI) to create a prodrug strategy for multi-modal chemotherapeutics.[7]
Awards and honours
Her awards and honours include:
Selected publications
Her publications include:
- Book: Marmion, Celine. Metal-based Anticancer Agents. Royal Society of Chemistry. 2019. 9781788014069.
- Marmion. Celine J.. 2004. Hydroxamic Acids− An Intriguing Family of Enzyme Inhibitors and Biomedical Ligands. European Journal of Inorganic Chemistry. 2004. 15. 3003–3016. 10.1002/ejic.200400221.
- Marmion. Celine J.. 2000. Hydroxamic acids are nitric oxide donors. Facile formation of ruthenium(II)-nitrosyls and NO-mediated activation of guanylate cyclase by hydroxamic acids. Chemical Communications. 13. 1153–1154. 10.1039/B001631O.
Notes and References
- Web site: TU Dublin News. Dublin. T. U.. www.dit.ie. en. 2020-01-13.
- Web site: Dr Celine Marmion – Biography. www.ucd.ie. 2020-01-13.
- Web site: Profile. www.rcsi.com. en. 2020-01-13.
- Kenny. Reece G.. Chuah. Su Wen. Crawford. Alanna. Marmion. Celine J.. 2017. Platinum(IV) Prodrugs – A Step Closer to Ehrlich's Vision?. European Journal of Inorganic Chemistry. en. 2017. 12. 1596–1612. 10.1002/ejic.201601278. 1099-0682. free.
- Kenny. Reece G.. Marmion. Celine J.. 2019-01-23. Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?. Chemical Reviews. 119. 2. 1058–1137. 10.1021/acs.chemrev.8b00271. 30640441. 58630540 . 0009-2665.
- Ude. Ziga. Kavanagh. Kevin. Twamley. Brendan. Pour. Milan. Gathergood. Nicholas. Kellett. Andrew. Marmion. Celine J.. 2019-06-18. A new class of prophylactic metallo-antibiotic possessing potent anti-cancer and anti-microbial properties. Dalton Transactions. en. 48. 24. 8578–8593. 10.1039/C9DT00250B. 30946409. 92997127 . 1477-9234.
- Web site: €3.5m investment in research commercialisation unveiled. Harrington. James. 2018-10-30. Engineers Journal. en-US. 2020-01-13.
- Web site: Speakers – Celebrating Research – Past, Present, Future – Royal College Surgeons in Ireland. rcsi.ie. 2020-01-13.
- Web site: RCSI Dean's Academic Award. www.rcsi.ie. 2020-01-13.
- Web site: Past Recipients. inmedlogin. Irish Network of Healthcare Educators. en-US. 2020-01-13.
- Web site: Annual General Meeting 2017 Photo gallery Institute of Chemistry of Ireland. www.chemistryireland.org. 2020-01-13.
- Web site: Meet…. 2019-11-06. EuChemS Newsletters. en-US. 2020-01-13.