| Celia Barrios y Mazariegos de Reina | |
| Office: | First Mother of the Nation |
| Predecessor: | Office established |
| Successor: | Joaquina Cabrera |
| President: | José María Reina Barrios |
| Termstart: | 12 March 1892 |
| Termend: | 6 July 1897 |
| Birth Date: | 1 January 1834 |
| Death Date: | 5 July 1897 |
| Birth Place: | San Marcos Department, Guatemala |
| Death Place: | Guatemala City, Guatemala |
Celia Barrios Mazariegos de Reina (1 January 1834 - 5 July 1897) was the mother of President José María Reina Barrios and the 1st First Mother of Guatemala, and the sister of President Justo Rufino Barrios.[1]
Celia Barrios y Mazariegos was born in San Marcos in 1834, daughter of Simon Barrios and Antolina Mazariegos, and married Joaquín Reyna, in 1850. They were the parents of José María, Manuel, María and María Antonia.
When her son General José María Reina Barrios reached the presidency on 12 March 1892, Mrs. Barrios was proclaimed "First Mother of the Nation", being the first country in which this term was used and being his only successor Mrs. Joaquina Cabrera, mother of the lawyer Manuel Estrada Cabrera.
She died on July 5, 1897, while she was sleeping. Three days of national mourning were declared, the national flag waved at half mast; she was buried in San Marcos.