Cefteram Explained

Cefteram (INN) is a third-generation cephalosporin antibiotic.^[1]

Synthesis

The reaction of 7-aminocephalosporanic acid (1) with the methyl-substituted tetrazole (2) gives the intermediate (3). Protection with diazodiphenylmethane (4) produces (5). Amide formation with the thiazole carboxylic acid (6) gives (7), which is deprotected with trifluoroacetic acid to yield cefteram.^{[2] [3]}

Notes and References

1. Yamaguchi K, Ohno A, Takahashi S, Hayashi M, Yamanaka K, Hirakata Y, Mitsuyama J . [In vitro antibacterial activities of cefteram and other beta-lactam agents against recent clinical isolates] . The Japanese Journal of Antibiotics . 51 . 1 . 11–25 . January 1998 . 9557273 .
2. Web site: Cefteram . chemdrug.com . 2024-07-03.
3. US . 4489072 . Hiroshi Sadaki, et al. . patent . 1984-12-18 . 1981-09-23 . 1980-09-25 . Toyama Chemical Co Ltd.