Cefsulodin Explained

Cefsulodin is a third-generation cephalosporin antibiotic that is active against Pseudomonas aeruginosa and was discovered by Takeda Pharmaceutical Company in 1977.^{[1] [2] [3] [4]}

TAP Pharmaceuticals had a new drug application on file with FDA for cefsulodin under the brand name Cefonomil as of 1985.^[5]

Cefsulodin is most commonly used in cefsulodin-irgasan-novobiocin agar to select for Yersinia microorganisms.^[6] This agar is most often used in water and beverage testing.

Susceptibility data

The following represents MIC susceptibility data for various P. aeruginosa strains:^[7]

• Pseudomonas aeruginosa PA13 (resistant strain): 32 μg/ml
• Pseudomonas aeruginosa (wild-type, susceptible): 4 - 8 μg/ml

Notes and References

1. Web site: TOKU-E Technical Application Sheet . https://web.archive.org/web/20110927174740/https://www.toku-e.com/Upload/Products/Article/20110323002554.pdf . 27 September 2011 . dead.
2. Smith BR . Cefsulodin and ceftazidime, two antipseudomonal cephalosporins . Clinical Pharmacy . 3 . 4 . 373–85 . 1984 . 6380902 .
3. Neu HC, Scully BE . Activity of cefsulodin and other agents against Pseudomonas aeruginosa . Reviews of Infectious Diseases . 6 . Suppl 3. S667–77 . 1984 . 6443768 . 10.1093/clinids/6.supplement_3.s667 .
4. Wright DB . Cefsulodin . Drug Intelligence & Clinical Pharmacy . 20 . 11 . 845–9 . November 1986 . 3536385 . 10.1177/106002808602001104 . 243377437 .
5. News: Lupron Is First Abbott-Takeda Product to Reach U.S. Market. Pink Sheet. 15 April 1985.
6. Web site: BAM Media M35: Cefsulodin-Irgasan Novobiocin Agar or Yersinia Selective Agar. Food and Drug Administration. 2 September 2012.
7. Web site: Cefsulodin | the Antimicrobial Index Knowledgebase - TOKU-E.