Cefacetrile Explained

Cefacetrile (INN, also spelled cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic effective in gram-positive and gram-negative bacterial infections. It is a bacteriostatic antibiotic.^{[1] [2]} Cefacetrile is marketed under the trade names Celospor, Celtol, and Cristacef,^[3] and as Vetimast for the treatment of mammary infections in lactating cows.

Synthesis

It was made by reacting 7-ACA (7-aminocephalosporanic acid) with cyanoacetyl chloride in the presence of tributylamine.

Notes and References

1. Web site: Cefacetrile Summary Report. European Medicines Agency, Committee for Veterinary Medicinal Products. 1998. 2012-01-25. 2020-05-26. https://web.archive.org/web/20200526024746/https://www.ema.europa.eu/en/documents/mrl-report/cefacetrile-summary-report-1-committee-veterinary-medicinal-products_en.pdf. dead.
2. Book: Austria-Codex . Haberfeld H . Österreichischer Apothekerverlag . Vienna . 2007 . 2007/2008 . 978-3-85200-183-8 . German.
3. Horiuchi N, Oyakawa Y, Oka R, Fujiwara T . [Clinical evaluation of cephacetrile (Celtol) for respiratory infections (author's transl)] . The Japanese Journal of Antibiotics . 33 . 10 . 1145–55 . October 1980 . 7206219 .