CDC23 explained

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.^[1]

Function

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.

Interactions

CDC23 has been shown to interact with CDC27.^{[2] [3]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW . Identification of a cullin homology region in a subunit of the anaphase-promoting complex . Science . 279 . 5354 . 1219–22 . Feb 1998 . 9469815 . 10.1126/science.279.5354.1219 . 1998Sci...279.1219Y .
• Zhao N, Lai F, Fernald AA, Eisenbart JD, Espinosa R, Wang PW, Le Beau MM . Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias . Genomics . 53 . 2 . 184–90 . Oct 1998 . 9790767 . 10.1006/geno.1998.5473 .
• Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM . Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex . The Journal of Biological Chemistry . 274 . 20 . 14500–7 . May 1999 . 10318877 . 10.1074/jbc.274.20.14500 . free .
• Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM . Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons . Proceedings of the National Academy of Sciences of the United States of America . 96 . 20 . 11317–22 . Sep 1999 . 10500174 . 18031 . 10.1073/pnas.96.20.11317 . 1999PNAS...9611317G . free .
• Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM . The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex . Proceedings of the National Academy of Sciences of the United States of America . 97 . 16 . 8973–8 . Aug 2000 . 10922056 . 16806 . 10.1073/pnas.97.16.8973 . 2000PNAS...97.8973G . free .
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Reports . 1 . 3 . 287–92 . Sep 2000 . 11256614 . 1083732 . 10.1093/embo-reports/kvd058 .
• Walker MG . Drug target discovery by gene expression analysis: cell cycle genes . . 1 . 1 . 73–83 . May 2001 . 12188893 . 10.2174/1568009013334241 .
• Wang Q, Moyret-Lalle C, Couzon F, Surbiguet-Clippe C, Saurin JC, Lorca T, Navarro C, Puisieux A . Alterations of anaphase-promoting complex genes in human colon cancer cells . Oncogene . 22 . 10 . 1486–90 . Mar 2003 . 12629511 . 10.1038/sj.onc.1206224 . free .
• Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM . TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 . Current Biology . 13 . 17 . 1459–68 . Sep 2003 . 12956947 . 10.1016/S0960-9822(03)00581-5 . free . 2003CBio...13.1459V .
• Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM . Mitotic regulation of the human anaphase-promoting complex by phosphorylation . The EMBO Journal . 22 . 24 . 6598–609 . Dec 2003 . 14657031 . 291822 . 10.1093/emboj/cdg627 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP . Phosphoproteomic analysis of the developing mouse brain . Molecular & Cellular Proteomics . 3 . 11 . 1093–101 . Nov 2004 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R . Phosphoproteome analysis of the human mitotic spindle . Proceedings of the National Academy of Sciences of the United States of America . 103 . 14 . 5391–6 . Apr 2006 . 16565220 . 1459365 . 10.1073/pnas.0507066103 . 2006PNAS..103.5391N . free .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . Oct 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .

Notes and References

1. Web site: Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae).
2. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM . TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 . Current Biology . 13 . 17 . 1459–68 . Sep 2003 . 12956947 . 10.1016/S0960-9822(03)00581-5 . free . 2003CBio...13.1459V .
3. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM . The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex . Proceedings of the National Academy of Sciences of the United States of America . 97 . 16 . 8973–8 . Aug 2000 . 10922056 . 16806 . 10.1073/pnas.97.16.8973 . 2000PNAS...97.8973G . free .