| Official Name: | Cayo Santa María |
| Settlement Type: | Resort island and village |
| Pushpin Map: | Cuba |
| Pushpin Relief: | 1 |
| Pushpin Label Position: | none |
| Pushpin Map Caption: | Location of Cayo Santa Maria in Cuba |
| Pushpin Mapsize: | 280 |
| Subdivision Type: | Country |
| Subdivision Name: |  Cuba |
| Subdivision Type1: | Province |
| Subdivision Name1: | Villa Clara |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Caibarién |
| Timezone: | EST |
| Utc Offset: | -5 |
| Coordinates: | 22.6577°N -79°W |
| Elevation M: | 4 |
| Area Code: | +53-43 |
Cayo Santa María (Saint Mary Cay or "Key") is an island off Cuba's north central coast in the Jardines del Rey archipelago.[1] The island is linked by road and bridge to the town of Caibarién on the main island. Cayo Santa María is well known for its white sand beaches and luxury all-inclusive resorts.
The name "Cayo Santa María" is also used to refer to the whole resort area, comprising a chain of three islands connected by the causeway
The island is linked to the mainland near Caibarién by a 48 km causeway, part of the Road to Cayo Santa María, constructed between 1989 and 1999 by Campaña de Las Villas. The island is administered as part of Caibarién, a municipality of Villa Clara Province.