| Location: | Cayo Santa María Cuba |
| Coordinates: | 22.685°N -78.8837°W |
| Yearbuilt: | 1909 (first) |
| Yearlit: | 1955 (current) |
| Foundation: | concrete base |
| Construction: | cast iron tower |
| Shape: | tapered cylindrical tower with balcony and lantern |
| Marking: | white and red horizontal band tower, silver metalli lantern |
| Height: | 32m (105feet) |
| Focalheight: | 48m (157feet) |
| Lens: | first-order Fresnel lens |
| Characteristic: | Fl W 5s. |
| Country: | Cuba |
| Countrynumber: | CU-0325[1] |
Cayo Caiman Grande de Santa María Lighthouse is a Cuban lighthouse located in Cayo Santa María, a resort island of the municipality of Caibarién, Villa Clara Province.