| Games: | Central American and Caribbean Games |
| Year: | 2010 |
| Noc: | CAY |
| Location: | Mayagüez, Puerto Rico |
| Competitors: | 39 |
| Competitors Men: | 33 |
| Competitors Women: | 6 |
| Sports: | 8 |
| Gold: | 2 |
| Silver: | 2 |
| Bronze: | 3 |
| Rank: | 14 |
The Cayman Islands sent 39 athletes (33 males, 6 females)[1] to the XXIst Central American and Caribbean Games in Mayagüez, Puerto Rico, July 17 - August 1, 2010.[2]
The athletes participated in athletics (10), beach volleyball (2), equestrian (1), karate do (1), rugby (12), sailing (3), squash (4) and swimming (6).
See main article: Swimming at the 2010 Central American and Caribbean Games.