| Cayeux-en-Santerre | |
| Commune Status: | Commune |
| Arrondissement: | Montdidier |
| Canton: | Moreuil |
| Insee: | 80181 |
| Postal Code: | 80800 |
| Mayor: | Hélène Attagnant[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | CC Avre Luce Noye |
| Coordinates: | 49.8214°N 2.6°W |
| Elevation M: | 55 |
| Elevation Min M: | 49 |
| Elevation Max M: | 96 |
| Area Km2: | 5.44 |
Cayeux-en-Santerre (Picard: Tchéyu-in-Santérre) is a commune in the Somme department in Hauts-de-France in northern France.
The commune is situated on the D76 road, some 25miles southeast of Amiens.