| Cayambe | |
| Native Name: | Kayampi |
| Native Name Lang: | qu |
| Settlement Type: | City |
| Motto: | It is my passion (Es mi Pasion) |
| Pushpin Map: | Ecuador |
| Pushpin Map Caption: | Location of Cayambe within Pichincha and Ecuador |
| Coordinates: | 0.0439°N -78.1561°W |
| Subdivision Type: | County |
| Subdivision Name: | Ecuador |
| Subdivision Type1: | Province |
| Subdivision Type2: | Canton |
| Subdivision Name1: | Pichincha |
| Subdivision Name2: | Cayambe |
| Established Title2: | Legal creation |
| Established Date2: | July 23, 1883 |
| Parts Type: | Urban parishes |
| P1: | Ayora |
| Leader Name: | William Perugachi Cevalles (2009-2014) |
| Total Type: | City |
| Elevation M: | 2830 |
| Area Total Km2: | 11.71 |
| Population Total: | 44559 |
| Population As Of: | Census 2022-10-01 |
| Population Density Km2: | auto |
| Population Footnotes: | [1] |
| Timezone1: | ECT |
| Utc Offset1: | -5 |
| P2: | Cayambe |
| Blank Name: | Climate |
| Blank Info: | 14° Csb |
Cayambe is an agricultural service city (population 44,559 at the last census on October 1, 2022) in highland Ecuador. It lies at the foot of the Cayambe volcano. While the city is mainly peopled by mestizos, the surrounding rural population is primarily composed of indigenous people who are mainly involved in subsistence agriculture, dairy farming and procurement of lumber. It is the third-largest city in Pichincha Province.
Cayambe's indigenous people of today are descendants of the pre-Inca Kayambi people. The Kayambi were resistant to Inca expansion and were only definitively conquered by Huayna Capac (the eleventh Sapa Inca of the Inca Empire) after a bloody 20-year war. At that time, the Kayambi people adopted the Kichwa language, a dialect of the Quechua family of languages. Not long afterwards, in the 16th century, the first Spanish conquistadores arrived in the region. Kichwa survives in some of the hamlets today, while in others it has given way to Spanish.
The town of Cayambe is the seat of the canton of Cayambe.
The area hosts numerous flower plantations, whose products are destined for the overseas cut flower market. Among the local food products, better known are cheese and biscochos de Cayambe (a crumbly biscuit).