Cationic amino acid transporter 3 explained

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.^{[1] [2]}

SLC7A3 is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids.[supplied by OMIM]^[2]

See also

• Solute carrier family

Further reading

• Hosokawa H, Sawamura T, Kobayashi S, etal . Cloning and characterization of a brain-specific cationic amino acid transporter . J. Biol. Chem. . 272 . 13 . 8717–22 . 1997 . 9079705 . 10.1074/jbc.272.13.8717 . free .
• Ito K, Groudine M . A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain . J. Biol. Chem. . 272 . 42 . 26780–6 . 1997 . 9334265 . 10.1074/jbc.272.42.26780 . free.
• Hosokawa H, Ninomiya H, Sawamura T, etal . Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain . Brain Res. . 838 . 1–2 . 158–65 . 1999 . 10446328 . 10.1016/S0006-8993(99)01686-8 . 33405664 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Gilles W, Vulcu SD, Liewald JF, etal . Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3 . Biochim. Biophys. Acta . 1668 . 2 . 234–9 . 2005 . 15737334 . 10.1016/j.bbamem.2004.12.011 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Rotmann A, Vékony N, Gassner D, etal . Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane . Biochem. J. . 395 . 1 . 117–23 . 2006 . 16332251 . 10.1042/BJ20051558 . 1409692 .

Notes and References

1. Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI . Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues . Biochemistry . 40 . 41 . 12387–94 . Oct 2001 . 11591158 . 10.1021/bi011345c .
2. Web site: Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3.