Cathrin Brisken Explained

Cathrin Brisken
Nationality:German, Swiss
Associate Professor
Spouse:Gian-Paolo Dotto
Children:3
Website:https://www.epfl.ch/labs/brisken-lab/
Education:Medicine
Alma Mater:University of Göttingen
Discipline:Oncology
Workplaces:École Polytechnique Fédérale de Lausanne (EPFL)
Main Interests:Breast Cancer, Hormones

Cathrin Brisken (born in 1967 in Osnabrück, Germany) is a German and Swiss medical doctor, researcher, and professor at the École Polytechnique Fédérale de Lausanne (EPFL).[1] [2] Her research focuses on the mechanisms of hormonal control in breast cancer development.[3]

Career

Brisken obtained a doctoral degree in medicine in 1992 and a PhD in biophysics in 1993 from the University of Göttingen. She then pursued postdoctoral work in the laboratory of Robert Weinberg at the Whitehead Institute for Biomedical Research, MIT. In 2001, she was named assistant professor at the Massachusetts General Hospital Cancer Center. In 2002, she moved to Switzerland to work as an associate scientist at the Swiss Institute for Experimental Cancer Research in Lausanne. In 2005, she was named tenure-track assistant professor at EPFL, where she was promoted to associate professor in 2012. In January 2020, she was appointed professor at the Institute for Cancer Research in London, where she acts part time and leads the Laboratory of Endocrine Control Mechanisms and the Laboratory of In vivo Modelling.[4]

In 2015, she co-founded the International Cancer Prevention Institute together with Gian-Paolo Dotto.[5] [6]

Research

During her postdoctoral studies in Robert Weinberg's laboratory, Brisken combined in vivo tissue reconstitution approaches with mouse genetics, thereby contributing to the understanding that the female sex hormones, estrogens, progesterone, and prolactin act at sequential stages of mammary gland development, with the mammary epithelium as primary target.[7] [8] She also showed that steroid hormones act by paracrine mechanisms and identified specific secreted Wnt factors as essential mediators of progesterone.[9]

Brisken established her own group at EPFL in 2005. Research in her laboratory focuses on the cellular and molecular bases of estrogen, progesterone, and androgen receptor signaling in the breast and the respective roles of these hormones and hormonally active compounds in breast carcinogenesis. Brisken's laboratory aims to understand how recurrent exposures to endogenous and exogenous hormones contribute to breast cancer development in order to better prevent and treat the disease.

Brisken's laboratory has proposed novel genetic in vivo approaches and develops ex vivo and xenograft models using patient samples to study hormone action in human tissues in normal settings and during disease progression.[10] [11] [12] [13] In 2011, it provided evidence that bisphenol A, a common component of consumer products, has persistent effects on mammary gland development of female embryos whose mothers are exposed to environmentally-relevant doses, pointing to epigenetic events influencing life time breast cancer risk during a perinatal window.[14]

Distinctions

Brisken is a member of the Biological Protocol Working Group of the International Breast Cancer Study Group and of the Pezcoller Symposia Scientific Standing Committee.[15] She served as the Dean of the EPFL Doctoral School from 2012 to 2014, as a member of the Hinterzartener Kreis for cancer research, of the oncology think-tank associated with the German Science Foundation, and of various Swiss, European, and AACR committees.[16] She was a member of the Women in Cancer Research Council of the American Association for Cancer Research from 2016 to 2020.[17] [18]

Personal life

Brisken is married to fellow cancer researcher Gian-Paolo Dotto and they have three children. She speaks eight languages including English.[19]

External links

Notes and References

  1. Web site: ORCID. Cathrin Brisken (0000-0002-6857-3230). 2020-11-10. orcid.org. en.
  2. Web site: Cathrin Brisken. 2020-11-10. people.epfl.ch.
  3. Web site: Research Activities. 2020-11-10. www.epfl.ch. en-GB.
  4. Web site: Professor Cathrin Brisken - The Institute of Cancer Research, London. 2020-11-10. www.icr.ac.uk.
  5. Web site: International Cancer Prevention Institute – Interdisciplinary research, exchange and education in cancer prevention. 2020-11-12. en-US.
  6. Web site: ICPI – A global forum for researchers, educators and policy makers to advance the prevention of cancer. 2020-11-10. www.icpi-web.org.
  7. Brisken. Cathrin. Park. Sissela. Vass. Tibor. Lydon. John P.. O’Malley. Bert W.. Weinberg. Robert A.. 1998-04-28. A paracrine role for the epithelial progesterone receptor in mammary gland development. Proceedings of the National Academy of Sciences of the United States of America. 95. 9. 5076–5081. 10.1073/pnas.95.9.5076. 0027-8424. 9560231. 20216. 1998PNAS...95.5076B. free .
  8. 1999-06-01. Prolactin Controls Mammary Gland Development via Direct and Indirect Mechanisms. Developmental Biology. en. 210. 1. 96–106. 10.1006/dbio.1999.9271. 0012-1606. Brisken. Cathrin. Kaur. Sarabjeet. Chavarria. Tony E.. Binart. Nadine. Sutherland. Robert L.. Weinberg. Robert A.. Kelly. Paul A.. Ormandy. Christopher J.. 10364430. free.
  9. Brisken. Cathrin. Heineman. Anna. Chavarria. Tony. Elenbaas. Brian. Tan. Jian. Dey. Sudhansu K.. McMahon. Jill A.. McMahon. Andrew P.. Weinberg. Robert A.. 2000-03-15. Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes & Development. 14. 6. 650–654. 10.1101/gad.14.6.650 . 0890-9369. 10733525. 316462.
  10. Sflomos. George. Dormoy. Valerian. Metsalu. Tauno. Jeitziner. Rachel. Battista. Laura. Scabia. Valentina. Raffoul. Wassim. Delaloye. Jean-Francois. Treboux. Assya. Fiche. Maryse. Vilo. Jaak. 2016-03-14. A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response. Cancer Cell. 29. 3. 407–422. 10.1016/j.ccell.2016.02.002. 1878-3686. 26947176. free.
  11. Beleut. Manfred. Rajaram. Renuga Devi. Caikovski. Marian. Ayyanan. Ayyakkannu. Germano. Davide. Choi. Yongwon. Schneider. Pascal. Brisken. Cathrin. 2010-02-16. Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proceedings of the National Academy of Sciences of the United States of America. 107. 7. 2989–2994. 10.1073/pnas.0915148107. 1091-6490. 2840294. 20133621. 2010PNAS..107.2989B. free .
  12. Tanos. Tamara. Sflomos. George. Echeverria. Pablo C.. Ayyanan. Ayyakkannu. Gutierrez. Maria. Delaloye. Jean-Francois. Raffoul. Wassim. Fiche. Maryse. Dougall. William. Schneider. Pascal. Yalcin-Ozuysal. Ozden. 2013-04-24. Progesterone/RANKL is a major regulatory axis in the human breast. Science Translational Medicine. 5. 182. 182ra55. 10.1126/scitranslmed.3005654. 1946-6242. 23616122. 22209269. 11147/5293. free.
  13. Web site: Breast cancer: An improved animal model opens up new treatments. 2020-11-11. ScienceDaily. en.
  14. Ayyanan. Ayyakkannu. Laribi. Ouahiba. Schuepbach-Mallepell. Sonia. Schrick. Christina. Gutierrez. Maria. Tanos. Tamara. Lefebvre. Gregory. Rougemont. Jacques. Yalcin-Ozuysal. Özden. Brisken. Cathrin. November 2011. Perinatal Exposure to Bisphenol A Increases Adult Mammary Gland Progesterone Response and Cell Number. Molecular Endocrinology. 25. 11. 1915–1923. 10.1210/me.2011-1129. 0888-8809. 5417179. 21903720.
  15. Web site: THE 31ST SYMPOSIUM. 2020-11-11. www.pezcoller.it.
  16. Web site: Scientific Achievement Awards Committees AACR Governance. 2020-11-11. American Association for Cancer Research (AACR). en.
  17. Web site: Brisken ICPI. 2020-11-11. www.icpi-web.org.
  18. Web site: AM18 Program. live. https://web.archive.org/web/20201111141229/https://www.aacr.org/wp-content/uploads/2019/12/AM18_Program.pdf . 2020-11-11 . 11 November 2020.
  19. News: Elle parle neuf langues, dont celle des hormones. fr. 24 heures. 2020-11-11. 1424-4039.

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