Catherine Blish Explained

Catherine Blish
Citizenship:United States
Known For:Innate immune system, HIV/AIDS, NK cells
Workplaces:Stanford University
Website:https://med.stanford.edu/blishlab.html
Fields:Immunology
Education:BS, University of California, Davis, Biochemistry (1993)PhD, University of Washington, Immunology (1999)MD, University of Washington (2001)Residency: University of Washington Medical Center (2003)American Board of Internal Medicine, Infectious Diseases (2006)
Awards:ICAAC Young Investigator Award, American Society for Microbiology (2010)NIH Director's New Innovator Award, National Institutes of Health (2013)

Elected Member, American Society for Clinical Investigation (2016)Fellow, Infectious Diseases Society of America (2017)Chan Zuckerberg Investigator (2017)

Catherine Blish is a translational immunologist and professor at Stanford University. Her lab works on clinical immunology and focuses primarily on the role of the innate immune system in fighting infectious diseases like HIV, dengue fever, and influenza. Her immune cell biology work characterizes the biology and action of Natural Killer (NK) cells and macrophages.[1]

For her previous and ongoing work fighting HIV/AIDS, Blish was awarded the 2018 Avant-Garde Award from the National Institute on Drug Abuse.[2]

Contributions to immunology

Natural Killer cell immune memory

A key concept in the adaptive immune system, and the foundational science behind vaccines, is that some elements of the immune system recognizes antigens it has seen before in a process called as immunological memory.[3] Dr. Blish and colleagues have identified a potential mechanism through which NK cells may also display immune memory.[4] This is unusual and shifts the accepted paradigm because NK cells are typically considered part of the innate immune system, not the adaptive immune system. Dr. Blish and colleagues demonstrate antigen-specific recognition, and memory of viruses and viral antigens by NK cells in mice and primates.

Key papers

The papers authored or co-authored by Dr. Blish that have been cited ~100 or more times are:

COVID-19

In 2020, Dr. Blish's lab pivoted to work on SARS-CoV-2 due to the COVID-19 pandemic.[12] [13] With colleagues, the Blish lab is scrutinizing ways chloroquine interferes with the viral life cycle.[14]

Honors

Notes and References

  1. Web site: 2020-04-27. Catherine Blish: Immunology is on the trail of a killer . 2020-07-12. Stanford School of Engineering. en.
  2. Web site: 2018-03-13. NIDA's 2018 Avant-Garde awards highlight immune response and killer cells. 2020-07-12. National Institutes of Health (NIH). EN.
  3. Book: Immunobiology 5 : the immune system in health and disease. 2001. Garland Pub. Janeway, Charles.. 978-0-8153-3642-6. 5th. New York. 45708106.
  4. Paust S, Blish CA, Reeves RK . Redefining Memory: Building the Case for Adaptive NK Cells . Journal of Virology . 91 . 20 . e00169–17, e00169–17 . October 2017 . 28794018 . 5625515 . 10.1128/JVI.00169-17 . Pierson TC .
  5. Horowitz A, Strauss-Albee DM, Leipold M, Kubo J, Nemat-Gorgani N, Dogan OC, Dekker CL, Mackey S, Maecker H, Swan GE, Davis MM, Norman PJ, Guethlein LA, Desai M, Parham P, Blish CA . 6 . Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry . Science Translational Medicine . 5 . 208 . 208ra145 . October 2013 . 24154599 . 3918221 . 10.1126/scitranslmed.3006702 .
  6. Grow EJ, Flynn RA, Chavez SL, Bayless NL, Wossidlo M, Wesche DJ, Martin L, Ware CB, Blish CA, Chang HY, Pera RA, Wysocka J . 6 . Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells . Nature . 522 . 7555 . 221–5 . June 2015 . 25896322 . 10.1038/nature14308 . 4503379 . 2015Natur.522..221G .
  7. Piantadosi A, Panteleeff D, Blish CA, Baeten JM, Jaoko W, McClelland RS, Overbaugh J . Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progression . Journal of Virology . 83 . 19 . 10269–74 . October 2009 . 19640996 . 2748011 . 10.1128/JVI.01149-09 .
  8. Blish CA, Dogan OC, Derby NR, Nguyen MA, Chohan B, Richardson BA, Overbaugh J . Human immunodeficiency virus type 1 superinfection occurs despite relatively robust neutralizing antibody responses . Journal of Virology . 82 . 24 . 12094–103 . December 2008 . 18842728 . 2593335 . 10.1128/JVI.01730-08 .
  9. Strauss-Albee DM, Fukuyama J, Liang EC, Yao Y, Jarrell JA, Drake AL, Kinuthia J, Montgomery RR, John-Stewart G, Holmes S, Blish CA . 6 . Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility . Science Translational Medicine . 7 . 297 . 297ra115 . July 2015 . 26203083 . 10.1126/scitranslmed.aac5722 . 4547537 .
  10. Blish CA, Nguyen MA, Overbaugh J . Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41 . PLOS Medicine . 5 . 1 . e9 . January 2008 . 18177204 . 10.1371/journal.pmed.0050009 . 2174964 . free .
  11. Blish CA, Nedellec R, Mandaliya K, Mosier DE, Overbaugh J . 25982588 . HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry . AIDS . 21 . 6 . 693–702 . March 2007 . 17413690 . 10.1097/qad.0b013e32805e8727 . free .
  12. Web site: 2020-04-30. Coronavirus: Repurposing drugs to protect human cells. 2020-07-12. The Mercury News. en-US.
  13. Web site: Zhang. Sarah . vanc . 2020-03-23. Why a Tiny Colorado County Can Offer COVID-19 Tests to Every Resident. 2020-07-12. The Atlantic. en-US.
  14. Web site: Goldman. Author Bruce . 2020-05-05. How chloroquine, coronavirus duke it out inside a dish. 2020-07-12. Scope. en-US.
  15. Web site: Kaiser. 8 February 2017. Jocelyn. Chan Zuckerberg Biohub funds first crop of 47 investigators. 2020-09-13. Science AAAS. en.
  16. Web site: A Push for Biomedical Innovation: Three Chan Zuckerberg Biohub Stories. live. https://web.archive.org/web/20190204074057/http://medicine.stanford.edu:80/2019-report/zuckerberg-biohub-stories.html . 2019-02-04 . 2020-09-13. Department of Medicine. Stanford University. en.
  17. Web site: 2015-08-05. NIH Announces 2013 High-Risk, High-Reward Research Awards. 2020-09-13. National Institutes of Health (NIH). EN.

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