| Castrignano del Capo | |
| Official Name: | Comune di Castrignano del Capo |
| Shield Alt: | Coat of arms |
| Pushpin Label Position: | left |
| Coordinates: | 39.85°N 20°W |
| Province: | Lecce (LE) |
| Frazioni: | Giuliano di Lecce, Salignano, Santa Maria di Leuca |
| Mayor: | Francesco Petracca |
| Area Total Km2: | 20.27 |
| Population Total: | 5113 |
| Population As Of: | 1 January 2022 |
| Population Demonym: | Castrignanesi |
| Elevation M: | 121 |
| Saint: | St. Michael Archangel |
| Day: | September 29 |
| Postal Code: | 73040 |
| Area Code: | 0833 |
Castrignano del Capo (Salentino: Sicilian: Casṭṛignanu) is a town and comune in the province of Lecce in the Apulia region of south-east Italy. It has three Villages: Santa Maria di Leuca, Giuliano, Salignano.