| caspase 4, apoptosis-related cysteine peptidase | |
| Width: | 240px |
| Hgncid: | 1505 |
| Symbol: | CASP4 |
| Altsymbols: | ICE(rel)II, ICH-2, TX |
| Entrezgene: | 837 |
| Omim: | 602664 |
| Refseq: | NM_001225 |
| Uniprot: | P49662 |
| Ecnumber: | 3.4.22.57 |
| Chromosome: | 11 |
| Arm: | q |
| Band: | 22.2-q22.3 |
| Substrate: | LEVD- |
Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.[1]
The anti-inflammatory drug indoprofen is an inhibitor of the activity of the caspase-4 enzyme.[2]