Caspase-2 Explained
| Caspase-2 |
| Ec Number: | 3.4.22.55 |
| Cas Number: | 182372-14-1 |
Caspase-2 (ICH-1, NEDD-2, caspase-2L, caspase-2S, neural precursor cell expressed developmentally down-regulated protein 2, CASP-2, NEDD2 protein) is an enzyme.[1] [2] [3] [4] [5] [6] This enzyme catalyses the following chemical reaction
Strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-
Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63).
Notes and References
- Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA . Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme . Genes & Development . 8 . 14 . 1613–26 . July 1994 . 7958843 . 10.1101/gad.8.14.1613 . free .
- Wang L, Miura M, Bergeron L, Zhu H, Yuan J . Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death . Cell . 78 . 5 . 739–50 . September 1994 . 8087842 . 10.1016/S0092-8674(94)90422-7 .
- Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A, Yuan J . Activation of caspase-2 in apoptosis . The Journal of Biological Chemistry . 272 . 34 . 21010–7 . August 1997 . 9261102 . 10.1074/jbc.272.34.21010 . free .
- Mancini M, Machamer CE, Roy S, Nicholson DW, Thornberry NA, Casciola-Rosen LA, Rosen A . Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis . The Journal of Cell Biology . 149 . 3 . 603–12 . May 2000 . 10791974 . 2174848 . 10.1083/jcb.149.3.603 .
- Zhivotovsky B, Orrenius S . Caspase-2 function in response to DNA damage . Biochemical and Biophysical Research Communications . 331 . 3 . 859–67 . June 2005 . 15865942 . 10.1016/j.bbrc.2005.03.191 . free .
- Howard Y. Chang . Chang HY, Yang X . Proteases for cell suicide: functions and regulation of caspases . Microbiology and Molecular Biology Reviews . 64 . 4 . 821–46 . December 2000 . 11104820 . 99015 . 10.1128/mmbr.64.4.821-846.2000 .
