Cas2 Explained

Symbol:	cas2
CRISPR-associated protein 2
Pfam:	PF09827
Interpro:	IPR019199

Cas2 is a protein associated with CRISPR that is involved with spacer acquisition. Representative cas2 proteins have been characterized as endonucleases that cleave single-stranded RNAs preferentially within U-rich regions, ^[1] or as metal-dependent endonucleases targeting double-stranded (ds)DNA ^[2]

Notes and References

1. Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, Kochinyan S, Wang S, Chruszcz M, Minor W, Koonin EV, Edwards AM, Savchenko A, Yakunin AF . 6 . A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats . The Journal of Biological Chemistry . 283 . 29 . 20361–71 . July 2008 . 18482976 . 2459268 . 10.1074/jbc.M803225200 . free .
2. Nam KH, Ding F, Haitjema C, Huang Q, DeLisa MP, Ke A . Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein . The Journal of Biological Chemistry . 287 . 43 . 35943–52 . October 2012 . 22942283 . 3476262 . 10.1074/jbc.M112.382598 . free .