| Carpignano Salentino | |
| Official Name: | Comune di Carpignano Salentino |
| Shield Alt: | Coat of arms of Carpignano |
| Pushpin Label Position: | left |
| Coordinates: | 40.197°N 18.3384°W |
| Province: | (LE) |
| Area Total Km2: | 48 |
| Population Footnotes: | [1] |
| Population Total: | 3854 |
| Population As Of: | November 2008 |
| Population Demonym: | Carpignanesi |
| Elevation M: | 76 |
| Saint: | Saint Antonio and the Madonna "della Grotta" |
| Day: | 2–3 July |
| Postal Code: | 73020 |
| Area Code: | 0836 |
| Istat: | 075015 |
| Frazioni: | Cannole, Castrignano de' Greci, Cursi, Martano, Melendugno, Otranto |
Carpignano Salentino (Salentino: Sicilian: Carpignanu) is a town and comune in the Italian province of Lecce in the Apulia region of south-east Italy. It includes the frazione of Serrano.