Carolyn Lawrence-Dill Explained

Carolyn Lawrence-Dill
Birth Date:18 May 1974
Birth Place:El Paso, Texas, U.S.
Fields:Plant Biology
Bioinformatics
Workplaces:Agricultural Research Service, Iowa State University
Alma Mater:University of Georgia
Texas Tech University
Hendrix College
Doctoral Advisor:R. Kelly Dawe & Russell L. Malmberg
Known For:Plant science data access and availability; gene function prediction tools and resources; making phenotype descriptions computable, research community-building

Carolyn Joy Lawrence-Dill (born May 18, 1974) is an American plant biologist and academic administrator. She develops computational systems and tools to help plant science researchers use plant genetics and genomics data for basic biology applications that advance plant breeding.

Early life and education

Carolyn Joy Lawrence-Dill, née Cogburn, was born in El Paso, Texas. She grew up in Throckmorton, then moved to Cleburne in 1989. She graduated in 1992 from Cleburne High School. Lawrence-Dill earned a B.A. degree in biology from Hendrix College in 1996. She received her M.S. degree in biology in 1997 from Texas Tech University where she worked on cotton physiology, and her Ph.D. degree in botany in 2003 from the University of Georgia. Her doctoral dissertation focused on integrating traditional and computational methods for inferring gene function in plants.[1]

Career

Following her formal education, Lawrence-Dill served for two years as a postdoctoral researcher under the direction of Volker Brendel[2] at Iowa State University.

In the summer of 2005, Lawrence-Dill began work as a research geneticist for the USDA-ARS. She served as the director of MaizeGDB, the maize model organism database through December 2013. In 2014 she joined the faculty of Iowa State University as an associate professor in the Departments of Genetics, Development and Cell Biology and Agronomy. In 2019 she was promoted to the rank of professor. In 2021, she was named Associate Dean for Research and Discovery for the Iowa State University College of Agriculture and Life Sciences and Associate Director of the Iowa Agriculture and Home Economics Experiment Station. In 2024, she joined Colorado State University as Dean of the College of Agricultural Sciences.[3]

Research

Lawrence-Dill's research focuses on mapping genomes and gene elements,[4] [5] [6] [7] predicting protein function,[8] [9] inventing new ways to link genes to phenotypic descriptions and images,[10] [11] developing ways to compute on phenotypic descriptions,[12] [13] [14] [15] organizing broad datasets for community access and use,[16] [17] [18] and developing computational tools that enable others to do all of these sorts of analyses directly. Although research and development projects are across the plant kingdom generally, much of her work focuses on maize.

Genomics

Lawrence-Dill has advanced plant scientists' ability to access plant genomics resources by sequencing and assembling genomes, annotating structural elements including genes, regulatory elements and CRISPR sites to genomes, and creating tools that enable researchers to analyze gene expression data.

Phenomics

Lawrence-Dill has advanced plant scientists' ability to compute on phenotype directly via connecting image-based phenotypes to genomics data, crowdsourcing for image-based machine learning, managing information for field and controlled environment high-throughput phenotyping, and computing on phenotypic descriptions.

Leadership and policy

Data sharing

Much of the work Lawrence-Dill has published seeks to advance data sharing to enable researchers to make use of others' findings, as some scientists harbor concerns about data sharing that those who generate materials and data will not derive prominence from downstream use and benefits derived from their own data.[19] However, generally limiting access to data prevents researchers from being able to test whether research results are reproducible. With respect to genomics data and materials, limiting access to digital sequence information (DSI) relevant to specific germplasm can keep researchers from being able to identify biological materials for novel research applications.

Climate and genetic engineering

Lawrence-Dill regularly addresses timely topics like climate change and genetic engineering, advising colleagues to engage in discussions on these topics with colleagues in other disciplines, with policymakers, and with the general public. Her guidance focuses on finding shared values, articulating social, environmental, and economic opportunities, and appealing to a better future rather than negative consequences.

In 2016, Lawrence-Dill and sociologist Shawn Dorius began work to better understand where negative public opinions on GMOs and climate change originate. While investigating how GMOs were portrayed in US news coverage, information on Russian interference in the 2016 United States elections emerged, with English language Russian state news from RT and Sputnik being ordered to register as foreign agents. This led the team to look into news reported by RT and Sputnik, where they found their portrayal of GMO topics to be very different from that in US media. Russian state news about GMOs was almost entirely negative, with seemingly intentional mis-associations linking GMOs with controversial, unrelated, and distasteful topics (e.g., topics on abortions of Zika-infected fetuses and the Trans-Pacific Partnership). The team hypothesized that this sort of activity could aim not only to stir up controversy in the US, but that to serve economic interests in Russia given that Russia’s number two industry is agriculture.

While their findings were under peer review, the Des Moines Register released a front-page article[20] describing their findings (February 25, 2018). The researchers released a preprint of the article via the SocArXiv[21] within a day to ensure that detailed materials, methods, and interpretations of the data were fully available. A media frenzy followed with coverage in more than 80 newspapers, online websites, and radio broadcasts, with audio coverage through National Public Radio’s Marketplace (February 28, 2018) and Iowa Public Radio’s River to River (March 2, 2018). There was even a political cartoon released by Greg Kearney,[22] and Bill Gates defended GMOs via a Reddit Ask Me Anything[23] discussion in the midst of the coverage. The peer-reviewed publication[24] was accepted March 11, 2018. Subsequent to media coverage of the GMO-Russia connections, reports of other seemingly unrelated hot topics showed signs of Russian influence with apparent intention to cause discord,[25] with demonstrations of influence campaigns emerging on wide-ranging topics from energy to human rights to international trade.

Scientific community building

Lawrence-Dill has brought together researchers across many communities to coordinate their work. This includes building consensus for standards and nomenclature,[26] [27] founding community organizations,[28] [29] and encouraging others through mentorship and training opportunities.[30]

Awards

Elected service

External links

Websites

Podcasts

Seminars

Notes and References

  1. https://athenaeum.libs.uga.edu/handle/10724/21098/ Dissertation Carolyn Joy Lawrence: A combined bioinformatic/molecular-based approach to understanding molecular motors in plants
  2. Web site: Brendel . Volker . Volker Brendel, Professor of Biology . Department of Biology, Indiana University . en.
  3. Web site: Lawrence-Dill named dean of CSU College of Agricultural Sciences . The Fence Post . en.
  4. Andorf . Carson M. . Kopylov . Mykhailo . Dobbs . Drena . Koch . Karen E. . Stroupe . M. Elizabeth . Lawrence . Carolyn J. . Bass . Hank W. . G-Quadruplex (G4) Motifs in the Maize (Zea mays L.) Genome Are Enriched at Specific Locations in Thousands of Genes Coupled to Energy Status, Hypoxia, Low Sugar, and Nutrient Deprivation . Journal of Genetics and Genomics . December 2014 . 41 . 12 . 627–647 . 10.1016/j.jgg.2014.10.004. 25527104 . free .
  5. Law . MeiYee . Childs . Kevin L. . Campbell . Michael S. . Stein . Joshua C. . Olson . Andrew J. . Holt . Carson . Panchy . Nicholas . Lei . Jikai . Jiao . Dian . Andorf . Carson M. . Lawrence . Carolyn J. . Ware . Doreen . Shiu . Shin-Han . Sun . Yanni . Jiang . Ning . Yandell . Mark . Automated Update, Revision, and Quality Control of the Maize Genome Annotations Using MAKER-P Improves the B73 RefGen_v3 Gene Models and Identifies New Genes . Plant Physiology . 1 January 2015 . 167 . 1 . 25–39 . 10.1104/pp.114.245027. 25384563 . 4280997 .
  6. Campbell . Michael S. . Law . MeiYee . Holt . Carson . Stein . Joshua C. . Moghe . Gaurav D. . Hufnagel . David E. . Lei . Jikai . Achawanantakun . Rujira . Jiao . Dian . Lawrence . Carolyn J. . Ware . Doreen . Shiu . Shin-Han . Childs . Kevin L. . Sun . Yanni . Jiang . Ning . Yandell . Mark . MAKER-P: A Tool Kit for the Rapid Creation, Management, and Quality Control of Plant Genome Annotations . Plant Physiology . 1 February 2014 . 164 . 2 . 513–524 . 10.1104/pp.113.230144. 24306534 . 3912085 . 11525262 .
  7. Manchanda . Nancy . Portwood . John L. . Woodhouse . Margaret R. . Seetharam . Arun S. . Lawrence-Dill . Carolyn J. . Andorf . Carson M. . Hufford . Matthew B. . GenomeQC: a quality assessment tool for genome assemblies and gene structure annotations . BMC Genomics . 2 March 2020 . 21 . 1 . 193 . 10.1186/s12864-020-6568-2. 32122303 . 7053122 . free .
  8. Wimalanathan . Kokulapalan . Lawrence-Dill . Carolyn J. . Gene Ontology Meta Annotator for Plants . Plant Methods . 18 October 2019 . 10.1101/809988. 208587945 .
  9. Wimalanathan . Kokulapalan . Friedberg . Iddo . Andorf . Carson M. . Lawrence-Dill . Carolyn J. . Maize GO Annotation-Methods, Evaluation, and Review (maize-GAMER) . Plant Direct . April 2018 . 2 . 4 . e00052 . 10.1002/pld3.52. 31245718 . 6508527 . 90386060 .
  10. Cho . Kyoung Tak . Portwood . John L. . Gardiner . Jack M. . Harper . Lisa C. . Lawrence-Dill . Carolyn J. . Friedberg . Iddo . Andorf . Carson M. . MaizeDIG: Maize Database of Images and Genomes . Frontiers in Plant Science . 28 August 2019 . 10 . 1050 . 10.3389/fpls.2019.01050. 31555312 . 6724615 . free .
  11. Zhou . Naihui . Siegel . Zachary D. . Zarecor . Scott . Lee . Nigel . Campbell . Darwin A. . Andorf . Carson M. . Dan Nettleton . Nettleton . Dan . Lawrence-Dill . Carolyn J. . Ganapathysubramanian . Baskar . Kelly . Jonathan W. . Friedberg . Iddo . Crowdsourcing image analysis for plant phenomics to generate ground truth data for machine learning . PLOS Computational Biology . 30 July 2018 . 14 . 7 . e1006337 . 10.1371/journal.pcbi.1006337. 30059508 . 6085066 . 2018PLSCB..14E6337Z . 51881800 . free .
  12. Oellrich . Anika . Walls . Ramona L . Cannon . Ethalinda . Cannon . Steven B . Cooper . Laurel . Gardiner . Jack . Gkoutos . Georgios V . Harper . Lisa . He . Mingze . Hoehndorf . Robert . Jaiswal . Pankaj . Kalberer . Scott R . Lloyd . John P . Meinke . David . Menda . Naama . Moore . Laura . Nelson . Rex T . Pujar . Anuradha . Lawrence . Carolyn J . Huala . Eva . An ontology approach to comparative phenomics in plants . Plant Methods . 2015 . 11 . 1 . 10 . 10.1186/s13007-015-0053-y. 25774204 . 4359497 . 18382593 . free .
  13. Braun . Ian . Lawrence-Dill . Carolyn . Computational Classification of Phenologs Across Biological Diversity . Proceedings of the 9th International Conference on Biological Ontology . 2018 . 2 . 2020-10-16 . 2019-01-14 . https://web.archive.org/web/20190114201049/http://ceur-ws.org/Vol-2285/ICBO_2018_paper_58.pdf . live .
  14. Braun . Ian R. . Lawrence-Dill . Carolyn J. . Automated Methods Enable Direct Computation on Phenotypic Descriptions for Novel Candidate Gene Prediction . Frontiers in Plant Science . 10 January 2020 . 10 . 1629 . 10.3389/fpls.2019.01629 . 31998331 . 6965352 . 210117404 . 1664-462X. free .
  15. Braun . Ian R. . Yanarella . Colleen F. . Lawrence-Dill . Carolyn J. . Computing on Phenotypic Descriptions for Candidate Gene Discovery and Crop Improvement . Plant Phenomics . 20 May 2020 . 2020 . 1–4 . 10.34133/2020/1963251. 33313544 . 7706311 . free .
  16. AlKhalifah . Naser . Campbell . Darwin A. . Falcon . Celeste M. . Gardiner . Jack M. . Miller . Nathan D. . Romay . Maria Cinta . Walls . Ramona . Walton . Renee . Yeh . Cheng-Ting . Bohn . Martin . Bubert . Jessica . Buckler . Edward S. . Ciampitti . Ignacio . Flint-Garcia . Sherry . Gore . Michael A. . Graham . Christopher . Hirsch . Candice . Holland . James B. . Hooker . David . Kaeppler . Shawn . Knoll . Joseph . Lauter . Nick . Lee . Elizabeth C. . Lorenz . Aaron . Lynch . Jonathan P. . Moose . Stephen P. . Murray . Seth C. . Nelson . Rebecca . Rocheford . Torbert . Rodriguez . Oscar . Schnable . James C. . Scully . Brian . Smith . Margaret . Springer . Nathan . Thomison . Peter . Tuinstra . Mitchell . Wisser . Randall J. . Xu . Wenwei . Ertl . David . Schnable . Patrick S. . De Leon . Natalia . Spalding . Edgar P. . Edwards . Jode . Lawrence-Dill . Carolyn J. . Maize Genomes to Fields: 2014 and 2015 field season genotype, phenotype, environment, and inbred ear image datasets . BMC Research Notes . December 2018 . 11 . 1 . 452 . 10.1186/s13104-018-3508-1. 29986751 . 6038255 . free .
  17. Lawrence . C. J. . MaizeGDB, the community database for maize genetics and genomics . Nucleic Acids Research . 1 January 2004 . 32 . 90001 . 393D–397 . 10.1093/nar/gkh011. 14681441 . 308746 .
  18. Duvick . J. . Fu . A. . Muppirala . U. . Sabharwal . M. . Wilkerson . M. D. . Lawrence . C. J. . Lushbough . C. . Brendel . V. . PlantGDB: a resource for comparative plant genomics . Nucleic Acids Research . 23 December 2007 . 36 . Database . D959–D965 . 10.1093/nar/gkm1041. 18063570 . 2238959 . 10046054 .
  19. Longo . Dan L. . Drazen . Jeffrey M. . Data Sharing . New England Journal of Medicine . 20 January 2016 . 374 . 3 . 276–277 . 10.1056/NEJMe1516564. 26789876 . free .
  20. News: Eller . Donnelle . Anti-GMO articles tied to Russian sites, ISU research shows . 15 October 2020 . Des Moines Register . 17 October 2020 . https://web.archive.org/web/20201017004244/https://www.desmoinesregister.com/story/money/agriculture/2018/02/25/russia-seeks-influence-usa-opinion-gmos-iowa-state-research/308338002/ . live .
  21. Dorius . Shawn F . Lawrence-Dill . Carolyn J . Sowing the seeds of skepticism: Russian state news and anti-GMO sentiment . GM Crops & Food . 27 February 2018 . 9 . 2 . 53–58 . 10.1080/21645698.2018.1454192 . 29561212 . 6277062.
  22. Web site: Kearney . G. M. . Drawing Attention . 15 October 2020 . 17 October 2020 . https://web.archive.org/web/20201017004216/https://drawing-attention.blogspot.com/2018/04/blog-post_12.html . live .
  23. Web site: Gates . Bill . r/IAmA - Comment by u/thisisbillgates on "I'm Bill Gates, co-chair of the Bill & Melinda Gates Foundation. Ask Me Anything." . reddit.
  24. Dorius . Shawn F. . Lawrence-Dill . Carolyn J. . Sowing the seeds of skepticism: Russian state news and anti-GMO sentiment . GM Crops & Food . 3 April 2018 . 9 . 2 . 53–58 . 10.1080/21645698.2018.1454192. 29561212 . 6277062 . 4051135 .
  25. News: Timberg . Craig . Romm . Tony . These provocative images show Russian trolls sought to inflame debate over climate change, fracking and Dakota pipeline . 20 October 2020 . Washington Post.
  26. Gray . John . Bevan . Michael . Brutnell . Thomas . Buell . C. Robin . Cone . Karen . Hake . Sarah . Jackson . David . Kellogg . Elizabeth . Lawrence . Carolyn . McCouch . Susan . Mockler . Todd . Moose . Stephen . Paterson . Andrew . Peterson . Thomas . Rokshar . Daniel . Souza . Glaucia Mendes . Springer . Nathan . Stein . Nils . Timmermans . Marja . Wang . Guo-Liang . Grotewold . Erich . A Recommendation for Naming Transcription Factor Proteins in the Grasses . Plant Physiology . January 2009 . 149 . 1 . 4–6 . 10.1104/pp.108.128504. 19126689 . 2613739 .
  27. Lawrence . Carolyn J. . Dawe . R. Kelly . Christie . Karen R. . Cleveland . Don W. . Dawson . Scott C. . Endow . Sharyn A. . Goldstein . Lawrence S.B. . Goodson . Holly V. . Hirokawa . Nobutaka . Howard . Jonathon . Malmberg . Russell L. . McIntosh . J. Richard . Miki . Harukata . Mitchison . Timothy J. . Okada . Yasushi . Reddy . Anireddy S.N. . Saxton . William M. . Schliwa . Manfred . Scholey . Jonathan M. . Vale . Ronald D. . Walczak . Claire E. . Wordeman . Linda . A standardized kinesin nomenclature . Journal of Cell Biology . 11 October 2004 . 167 . 1 . 19–22 . 10.1083/jcb.200408113. 15479732 . 2041940 . 30027277 .
  28. Carroll . April Agee . Clarke . Jennifer . Fahlgren . Noah . Gehan . Malia A. . Lawrence‐Dill . Carolyn J. . Lorence . Argelia . NAPPN: Who We Are, Where We Are Going, and Why You Should Join Us! . The Plant Phenome Journal . January 2019 . 2 . 1 . 1–4 . 10.2135/tppj2018.08.0006. 186567373 . free .
  29. Lawrence‐Dill . Carolyn J. . Schnable . Patrick S. . Springer . Nathan M. . Idea Factory: the Maize Genomes to Fields Initiative . Crop Science . July 2019 . 59 . 4 . 1406–1410 . 10.2135/cropsci2019.02.0071. free .
  30. Lawrence-Dill . Carolyn . Heindel . Theodore . Schnable . Patrick . Strong . Stephanie . Wittrock . Jill . Losch . Mary . Dickerson . Julie . Transdisciplinary Graduate Training in Predictive Plant Phenomics . Agronomy . 16 May 2018 . 8 . 5 . 73 . 10.3390/agronomy8050073. free .
  31. Web site: Maize Genetics Cooperation honors 2 faculty . Iowa State University . en . 2023-09-20.
  32. Web site: Women of Achievement . ywca . en . 2020-10-15 . 2020-10-17 . https://web.archive.org/web/20201017004244/https://www.ywcaames.org/women-of-achievement . live .
  33. Web site: IPPN Home . www.plant-phenotyping.org . 2020-10-15 . 2020-10-01 . https://web.archive.org/web/20201001023258/https://www.plant-phenotyping.org/ . live .
  34. Web site: North American Plant Phenotyping Network . nappn.plant-phenotyping.org . 2020-10-15 . 2020-06-12 . https://web.archive.org/web/20200612130133/http://nappn.plant-phenotyping.org/ . live .
  35. Web site: DivSeek International Network - A Global Community Driven Not-for-Profit Organization . DivSeek Intl . 2020-10-15 . 2020-10-17 . https://web.archive.org/web/20201017004218/https://divseekintl.org/ . live .
  36. Web site: Maize Genetics Executive Committee . maizegdb.org . 2020-10-15 . 2020-05-13 . https://web.archive.org/web/20200513015825/https://maizegdb.org/mgec . live .

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