| Consort: | yes |
| Caroline of Hesse-Darmstadt | |
| Succession: | Landgravine consort of Hesse-Homburg |
| Reign: | 27 September 1768 – 20 January 1820 |
| House: | Hesse |
| Father: | Louis IX, Landgrave of Hesse-Darmstadt |
| Mother: | Countess Palatine Caroline of Zweibrücken |
| Issue: | Frederick VI, Landgrave of Hesse-Homburg Louis William, Landgrave of Hesse-Homburg Caroline, Princess of Schwarzburg-Rudolstadt Louise, Princess Charles Günther of Schwarzburg-Rudolstadt Amalie, Hereditary Princess of Anhalt-Dessau Auguste, Hereditary Grand Duchess of Mecklenburg-Schwerin Philip, Landgrave of Hesse-Homburg Gustav, Landgrave of Hesse-Homburg Ferdinand, Landgrave of Hesse-Homburg Maria Anna, Princess of Prussia Prince Leopold |
| Birth Place: | Buchsweiler |
| Death Place: | Bad Homburg vor der Höhe |
Caroline of Hesse-Darmstadt (2March 174618September 1821) was Landgravine consort of Hesse-Homburg by marriage to Frederick V, Landgrave of Hesse-Homburg.
Caroline was born on 2 March 1746 in Buchsweiler. She was the eldest daughter of Louis IX, Landgrave of Hesse-Darmstadt and his wife Countess Palatine Caroline of Zweibrücken-Birkenfeld.
She married Frederick V, Landgrave of Hesse-Homburg on 27 September 1768. The marriage was contracted for diplomatic and political reasons as the symbol of an inheritance dispute between their respective families. Caroline and Frederick V produced many children but their marriage never developed into a personal relationship, and they lived mostly separated lives. Caroline often spent time in her villa in the forest near Homburg.
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