Caroline Relton Explained

Caroline Laura Relton
Workplaces:University of Bristol
London School of Hygiene and Tropical Medicine
Alma Mater:Newcastle University
Thesis Title:The identification and characterisation of genes associated with insulin resistance
Thesis Url:https://search.worldcat.org/en/title/40796911
Thesis Year:1998

Caroline Laura Relton is a British biochemist, Professor and Pro Director for Research and Academic Development at the London School of Hygiene and Tropical Medicine. Her research considers genetic and epigenetic epidemiology and looks to understand the role of DNA methylation in complex disease.

Early life and education

Relton studied applied biology and nutritional science as an undergraduate. She earned a postgraduate certificate in science education in 1990.[1] She was a doctoral research student in molecular genetics at Newcastle University. Her research involved investigations into genes associated with insulin resistance.[2] After completing her doctorate she was appointed to the faculty at Newcastle, a position she held for 12 years.[3]

Research and career

She moved to the University of Bristol in 2012. Relton investigates the variations in epidemiology that cause disease, and how these can be used to predict disease.[4] She uses population-based approaches to study how behavioural, psychological, and social variables relate to DNA methylation.[5] She was one of the first researchers to show that DNA could be a predictor of body weight: factors that influence the development of a baby in the womb (e.g. diet, smoking, stress) can predispose a child to obesity.[6] [7] Relton studied this using the Children of the 90s study. She used data from 520,000 people across Europe to demonstrate a link between levels of B vitamins and lung cancer, showing a reduced risk of lung cancer among people with high levels of Vitamin B6 and methionine.[8]

Alongside her research position at Bristol, Relton is Pro-Director of Research and Development at the London School of Hygiene and Tropical Medicine.[9]

Select publications

Notes and References

  1. Web site: Caroline Relton HCEO . 2024-03-30 . hceconomics.uchicago.edu.
  2. Web site: The identification and characterisation of genes associated with insulin resistance WorldCat.org . 2024-03-29 . search.worldcat.org . en.
  3. Web site: Richard Doll Seminar - Embracing epigenetics in epidemiological studies: uses in prediction and understanding disease mechanisms . 2024-03-30 . www.ndph.ox.ac.uk . en.
  4. Web site: Caroline Relton . 2024-03-29 . Bristol Biomedical Research Centre . en-GB.
  5. Web site: Bristol . University of . Caroline Relton . 2024-03-30 . www.bristol.ac.uk . en-GB.
  6. Web site: Bristol . University of . 2012: Children of the 90s News and features University of Bristol . 2024-03-30 . www.bristol.ac.uk . en-GB.
  7. Pearce . Mark S . Mann . Kay D . Relton . Caroline L . Francis . Roger M . Steele . James G . Craft . Alan W . Parker . Louise . May 2012 . How the Newcastle Thousand Families birth cohort study has contributed to the understanding of the impact of birth weight and early life socioeconomic position on disease in later life . Maturitas . 72 . 1 . 23–28 . 10.1016/j.maturitas.2012.02.005 . 22391388 . 0378-5122.
  8. Web site: 2010-06-16 . Region's scientists help in cancer breakthrough . 2024-03-30 . The Northern Echo . en.
  9. Web site: Executive Office Governance LSHTM . 2024-03-30 . www.lshtm.ac.uk . en.