Carol Lynn Curchoe Explained

Carol Lynn Curchoe
Birth Place:Manchester, Connecticut
Fields:Stem cell, cloning, epigenetics
Alma Mater:University of Connecticut, Sanford-Burnham Medical Research Institute
Thesis Title:Epigenetic reprogramming in cloned livestock
Thesis Url:https://www.worldcat.org/oclc/74494433
Thesis Year:2006
Known For:Former Utah State Science Advisor

Carol Lynn Curchoe (born in 1979 in Manchester, Connecticut), formerly Carol George, is an American reproductive biologist specializing in Molecular biology, Cell biology and Biotechnology. Her key contributions to those fields include advances in stem cell culture, epigenetics and reprogramming. She is the former Utah State Science Advisor,[1] President and CEO of 32ATPs,[2] domestic outreach director of We Love GMO's and Vaccines[3] and an author of personal essays and fiction.

Career

Academics

Curchoe earned an Associate of Science degree at Manchester Community College, a bachelor's degree, master's degree, and Ph.D. at the University of Connecticut[4] and performed her postdoctoral research at Sanford Burnham Prebys Medical Discovery Institute as a California Institute for Regenerative Medicine funded postdoctoral scholar.[5]

As an undergraduate researcher, Curchoe was part of a team that characterized the meat and milk composition of bovine clones[6] that informed the Food and Drug Administration's (FDA) decision about these products for general consumption.[7] Her dissertation research, performed at the University of Connecticut in the Physiology of Reproduction, and completed in three years, was one of the fastest graduate degrees ever earned at that university.[8] That work characterized the reprogramming of imprinted genes, such as IGF2,[9] IGF2R,[10] and H19[11] in cloned livestock.[12] [13]

Her California Institute for Regenerative Medicine postdoctoral work was performed at the Sanford Burnham Prebys Medical Discovery Institute in the field of human embryonic stem cell culture where she developed a protocol for the production of hESC derived neural precursors[14] and peripheral neurons,[15] specifically for therapeutic use. Additionally, she developed an in vitro model of early human neurulation events.[16]

As a Utah Valley University adjunct professor she taught mammalian cloning and biotechnology using project based learning, inverted classrooms, and community building through social media.

STEM Education Advocacy

From May 2013 to May 2014, Curchoe was the Utah State Science Advisor[4] to Governor Gary R. Herbert. She was responsible for a number of statewide science initiatives, including the Utah State STEM Action Center,[17] Utah Governor's Medal for Science and Technology, Work Ready Utah powered by ACT, and other workforce and advanced manufacturing initiatives.

In an article for Science Magazine, Curchoe stated "I have worked to pay it forward by acting as a mentor for girls and women in STEM, passing on the advice that has worked for me".[4]

Business career

After finishing her academic research Curchoe entered into business development as an associate at Sanford Burnham Prebys Medical Discovery Institute where she was part of a team that strengthened translational research by establishing clinical research partnerships with Pfizer, Takeda, and Johnson & Johnson. In 2010 she helped to launch the Office of Collaborative Science[18] at the New York University School of Medicine, which unified 17 disparate fee for service labs. Best practice models for tracking core-contributed publications[19] resulted.

Curchoe founded 32ATPs,[2] a company developing a biological supercapacitor which received an honorable mention at the 14th Annual Utah Innovation Awards in the category Clean Technology and Energy.[20] The project was initially crowd-sourced.[21] The company has applied for a patent for this technology.[22]

Curchoe is known to actively mentor women researchers, staff members and students who are just getting interested in a career in science. She credits the mentorship she received working in the laboratory of Dr. X. Cindy Tian for being able to earn a graduate degree after dropping out of high school.[4] Since relocating to Utah she has been involved with community initiatives such as Latinos in Action, Expanding Your Horizons[23] and Salt Lake Valley Science and Engineering Fair.[24]

Along with CJ Burton, Curchoe is co-founder of EduPaper Products,[25] an online store selling STEM-themed educational products.

Honors and awards

Peer-reviewed publications

Notes and References

  1. Web site: Utah Governor's Office of Economic Development 2013 Annual Report. Business.Utah.gov. Utah Governor's Office of Economic Development. 1 February 2017. https://web.archive.org/web/20170405170900/http://business.utah.gov/publications/state-science-advisor-2/. 5 April 2017. dead.
  2. Web site: 32ATPs. 32ATPs. 1 February 2017.
  3. Web site: About Us. We Love GMO's and Vaccines. 1 February 2017. https://web.archive.org/web/20170213025836/http://welovegv.com/about/. 13 February 2017. dead.
  4. Curchoe. Carol. The Power of Mentoring. Science. 350. 6259. 478. 2015Sci...350..478C. 2015. 10.1126/science.350.6259.478. 26494760. free.
  5. Web site: Carol Lynn Curchoe Is A STEM Warrior Princess. The Limit Does Not Exist. Forbes. 4 April 2017. 5 April 2017. https://web.archive.org/web/20170405172722/https://www.forbes.com/sites/christinawallace/2017/01/23/the-limit-does-not-exist-stem-warrior-princess/#45b2953b5c57. dead.
  6. 10.1073/pnas.0500140102 . Meat and milk compositions of bovine clones . 2005 . Tian . X. C. . Kubota . C. . Sakashita . K. . Izaike . Y. . Okano . R. . Tabara . N. . Curchoe . C. . Jacob . L. . Zhang . Y. . Smith . S. . Bormann . C. . Xu . J. . Sato . M. . Andrew . S. . Yang . X. . Proceedings of the National Academy of Sciences . 102 . 18 . 6261–6 . 15829585 . 1088367. 2005PNAS..102.6261T . free .
  7. Web site: Animal Cloning: A Risk Assessment. US FDA. 15 March 2017.
  8. Web site: HOMER, the UConn Libraries' catalog . homerweb.lib.uconn.edu . 27 January 2022 . https://archive.today/20140214221613/http://homerweb.lib.uconn.edu/cgi-bin/Pwebrecon.cgi?DB=local&BOOL1=all+of+these&FLD1=Keyword+Anywhere+(GKEY)&CNT=25+records+per+page&SAB1=74494433 . 14 February 2014 . dead.
  9. 10.1095/biolreprod.105.044727 . Promoter-Specific Expression of the Imprinted IGF2 Gene in Cattle (Bos taurus) . 2005 . Curchoe . C. . Biology of Reproduction . 73 . 6 . 1275–81 . 16120826 . Zhang . S . Bin . Y . Zhang . X . Yang . L . Feng . D . O'Neill . M . Tian . XC. free .
  10. 10.1016/j.anireprosci.2009.01.003 . Allelic switching of the imprinted IGF2R gene in cloned bovine fetuses and calves . 2009 . Suteevun-Phermthai . T. . Curchoe . C.L. . Evans . A.C. . Boland . E. . Rizos . D. . Fair . T. . Duffy . P. . Sung . L.Y. . Du . F. . Chaubal . S. . Xu . J. . Wechayant . T. . Yang . X. . Lonergan . P. . Parnpai . R. . Tian . X.C. . Animal Reproduction Science . 116 . 19–27 . 19217227 . 1–2.
  11. 10.1016/j.anireprosci.2009.02.008 . Hypomethylation trends in the intergenic region of the imprinted IGF2 and H19 genes in cloned cattle . 2009 . Curchoe . Carol Lynn . Zhang . Shouquan . Yang . Lan . Page . Raymond . Tian . X. Cindy . Animal Reproduction Science . 116 . 3–4 . 213–25 . 19282114.
  12. 10.1080/10495390701758563 . Genetic Imprinting ofH19andIGF2in Domestic Pigs (Sus scrofa) . 2008 . Li* . Chao . Bin . Yanfang . Curchoe . Carol . Yang . Lan . Feng . Dingyuan . Jiang . Qingyan . O'Neill . Michael . Tian . X. Cindy . Zhang . Shouquan . Animal Biotechnology . 19 . 22–7 . 18228173 . 1. 34695274 .
  13. 17491157 . 2007 . Tian . XC . Smith . SL . Zhang . SQ . Kubota . C . Curchoe . C . Xue . F . Yang . L . Du . F . Sung . LY . Yang . X . Nuclear reprogramming by somatic cell nuclear transfer--the cattle story . 64 . 327–39 . Society of Reproduction and Fertility Supplement. 10.5661/rdr-vi-327 .
  14. 10.1002/stem.107 . Nicotinamide Rescues Human Embryonic Stem Cell-Derived Neuroectoderm from Parthanatic Cell Death . 2009 . Cimadamore . Flavio . Curchoe . Carol Lynn . Alderson . Nazilla . Scott . Fiona . Salvesen . Guy . Terskikh . Alexey V. . Stem Cells . 27 . 8 . 1772–81 . 19544437 . 4151857.
  15. 10.1371/journal.pone.0013890 . Early Acquisition of Neural Crest Competence During hESCs Neuralization . 2010 . Najbauer . Joseph . Curchoe . Carol Lynn . Maurer . Jochen . McKeown . Sonja J. . Cattarossi . Giulio . Cimadamore . Flavio . Nilbratt . Mats . Snyder . Evan Y. . Bronner-Fraser . Marianne . Terskikh . Alexey V. . PLOS ONE . 5 . 11 . e13890 . 21085480 . 2976694. 2010PLoSO...513890C . free .
  16. 10.1016/j.scr.2011.11.003 . HESC derived neuro-epithelial rosettes recapitulate early mammalian neurulation events; an in vitro model . 2012 . Curchoe . Carol Lynn . Russo . Joseph . Terskikh . Alexey V. . Stem Cell Research . 8 . 2 . 239–46 . 22265743. free .
  17. Web site: STEM Action Center. STEM Action Center UTAH. 1 February 2017.
  18. Web site: Office of Collaborative Science. Division of Advanced Research Technologies. 1 February 2017.
  19. 23204927 . 10.7171/jbt.12-2304-003 . 23 . 4 . Method for tracking core-contributed publications . 3468145 . 2012 . J Biomol Tech . 122–7 . Loomis . CA . Curchoe . CL.
  20. Web site: Finalists Announced in 14th Annual Utah Innovation Awards. Utah Innovation Awards. Utah Technology Council. 14 March 2017.
  21. Web site: Can our cell's mitochondria power a cell phone?. experiment. experiment. 13 March 2017.
  22. Web site: Biological supercapacitor structure and method for manufacturing and use of the same. Patent Application Full Text and Image Database. US Patent & Trademark Office. 15 March 2017.
  23. http://www.eyhn.org/ Expanding Your Horizons
  24. https://slvsef.org/ Salt Lake Valley Science and Engineering Fair
  25. Web site: EduPaper Products. EduPaper Products. 13 March 2017. https://web.archive.org/web/20170405171250/https://www.edupaperproducts.com/. 5 April 2017. dead.
  26. Web site: Women Tech Council Announces 2016 Award Finalists Driving Technology, Innovation and Business. PRNewswire. PRNewswire. 1 February 2017.
  27. Web site: Forty Under 40 . 2014-02-27 . dead . https://web.archive.org/web/20150214015102/http://www.utahbusiness.com/articles/view/forty_under_4/?pg=2 . 2015-02-14 .
  28. Web site: 40 Under 40 Awards 2016. San Diego Metro Magazine. 11 September 2016. San Diego Metro Magazine. 20 April 2017.

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